Trends in viral hepatitis-related mortality in the United States from 1999 to 2022: A retrospective study

Table 8 Viral hepatitis annual percent change and average annual percent change in the age-adjusted mortality rate per 100000 people; stratified by region, 1999-2022

Cohort	Statistic	Segment	Years	Percent change	95%CI	P value
Northeast	APC	1	1999-2014	1.86	(0.67, 3.82)	P < 0.05
		2	2014-2019	-10.84	(-14.67, 2.90)
		3	2019-2022	-3.64	(-9.44, 3.40)
	AAPC	Full range	1999-2022	-1.76	(-2.39, -1.33)	P < 0.001
Midwest	APC	1	1999-2013	3.53	(2.77, 4.53)	P < 0.001
		2	2013-2022	-4.38	(-5.90, -3.15)	P < 0.001
	AAPC	Full range	1999-2022	0.36	(-0.10, 0.84)
South	APC	1	1999-2006	3.92	(3.06, 6.01)	P < 0.001
		2	2006-2015	1.67	(0.46, 2.21)	P < 0.05
		3	2015-2022	-5.26	(-6.10, -4.48)	P < 0.001
	AAPC	Full range	1999-2022	0.18	(-0.03, 0.43)
West	APC	1	1999-2013	3.53	(2.69, 4.53)	P < 0.001
		2	2013-2022	-7.13	(-8.69, -5.75)	P < 0.001
	AAPC	Full range	1999-2022	-0.78	(-1.28, -0.29)	P < 0.05

APC: Annual percentage change; AAPC: Average annual percentage change.