Trends in viral hepatitis-related mortality in the United States from 1999 to 2022: A retrospective study

Table 6 Viral hepatitis annual percent change and average annual percent change in the overall crude mortality rate per 100000 people; stratified by ten-year age groups, 1999-2022

Cohort	Statistic	Segment	Years	Percent change	95%CI	P value
25-34 years	APC	1	1999-2010	-3.57	(-5.81, -1.66)	P < 0.05
		2	2010-2020	4.24	(-1.05, 11.38)
		3	2020-2022	-10.14	(-18.83, 2.22)
	AAPC	Full range	1999-2022	-0.86	(-1.68, -0.03)	P < 0.05
35-44 years	APC	1	1999-2002	-0.18	(-3.32, 4.84)
		2	2002-2013	-7.34	(-8.64, -6.69)	P < 0.001
		3	2013-2022	-1.12	(-2.38, 0.83)
	AAPC	Full range	1999-2022	-4.03	(-4.41, -3.67)	P <0.001
45-54 years	APC	1	1999-2002	11.25	(7.38, 17.86)	P < 0.001
		2	2002 -2007	2.95	(-0.03, 4.62)
		3	2007-2014	-4.51	(-6.07, -3.44)	P < 0.001
		4	2014-2022	-12.90	(-14.28, -11.81)	P < 0.001
	AAPC	Full range	1999-2022	-4.10	(-4.52, -3.71)	P < 0.001
55-64 years	APC	1	1999-2005	9.64	(0.95, 13.63)	P < 0.05
		2	2005-2008	18.69	(6.24, 22.34)	P < 0.001
		3	2008-2014	6.28	(-10.65, 7.45)
		4	2014-2022	-9.50	(-10.56, -7.65)	P < 0.001
	AAPC	Full range	1999-2022	2.79	(2.29, 3.48)	P < 0.001
65-74 years	APC	1	1999-2004	-0.76	(-7.82, 3.34)
		2	2004-2011	4.25	(0.40, 10.89)	P < 0.05
		3	2011-2015	10.01	(-1.47, 13.73)
		4	2015-2022	1.27	(-0.89, 4.60)
	AAPC	Full range	1999-2022	3.20	(2.77, 3.85)	P < 0.001
75-84 years	APC	1	1999-2015	0.51	(-0.78, 1.36)
		2	2015-2019	-6.22	(-10.56, 2.02)
		3	2019-2022	4.24	(-2.43, 12.36)
	AAPC	Full range	1999-2022	-0.22	(-0.80, 0.20)
85+ years	APC	1	1999-2022	0.20	(-0.35, 0.83)
	AAPC	Full range	1999-2022	0.20	(-0.35, 0.83)

APC: Annual percentage change; AAPC: Average annual percentage change.