Trends in viral hepatitis-related mortality in the United States from 1999 to 2022: A retrospective study

Table 2 Viral hepatitis annual percent change and average annual percent change in the age-adjusted mortality rate per 100,000 people; overall and stratified by gender, 1999-2022

Cohort	Statistic	Segment	Years	Percent change	95%CI	P value
Overall	APC	1	1999-2013	3.20	(2.54, 3.99)	P < 0.001
		2	2013-2022	-5.54	(-6.75, -4.47)	P < 0.001
	AAPC	Full range	1999-2022	-0.31	(-0.69, 0.07)
Female	APC	1	1999-2013	2.64	(2.02, 3.38)	P < 0.001
		2	2013-2022	-5.15	(-6.45, -4.09)	P < 0.001
	AAPC	Full range	1999-2022	-0.48	(-0.87, -0.12)	P < 0.05
Male	APC	1	1999-2008	4.02	(3.10, 7.86)	P < 0.001
		2	2008-2014	1.75	(-6.82, 2.85)
		3	2014-2022	-6.06	(-7.50, -4.84)	P < 0.05
	AAPC	Full range	1999-2022	-0.18	(-0.50, 0.21)

APC: Annual percentage change; AAPC: Average annual percentage change.