Deep sequencing analysis of hepatitis B virus in patients with incomplete response to tenofovir alafenamide fumarate treatment

Figure 2 Alignment of reverse transcriptase regions of hepatitis B virus strains detected in tenofovir alafenamide fumarate-incomplete responders. The reverse transcriptase regions of the hepatitis B virus strains detected in tenofovir alafenamide fumarate (TAF)-incomplete responders before treatment (pre), 1 year after TAF treatment (1 year), and 2 years after TAF treatment (2 year) were directly sequenced, and deduced amino acids were aligned with the reference sequence of genotype C (accession number: GQ872210). The inverted triangle indicates the positions of the reported resistance-associated mutations to tenofovir disoproxil fumarate and TAF. A box with a dotted line indicates the positions of the mutations detected in this study. RT: Reverse transcriptase.