Deep sequencing analysis of hepatitis B virus in patients with incomplete response to tenofovir alafenamide fumarate treatment

Figure 1 Clinical courses of two tenofovir alafenamide fumarate-incomplete responders. Serum alanine aminotransferase levels (open circles), hepatitis B virus (HBV) DNA titers (open squares), HBV RNA titers (closed bars), and status of HBeAg are indicated. The lower limit of detection of HBV DNA is indicated by the dotted line. The serum samples were collected at the time points indicated by open arrows with numbers. ALT: Alanine aminotransferase; HBV: Hepatitis B virus; TAF: Tenofovir alafenamide fumarate; HBeAg: Hepatitis B e antigen.