Deep sequencing analysis of hepatitis B virus in patients with incomplete response to tenofovir alafenamide fumarate treatment

doi:10.4254/wjh.v17.i5.104519

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May 27, 2025 (publication date) through May 30, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. May 27, 2025; 17(5): 104519
Published online May 27, 2025. doi: 10.4254/wjh.v17.i5.104519

Table 2 Profile of two tenofovir alafenamide fumarate-incomplete responders

Patients	Patient A	Patient B
Genotype	C	C
HBsAg (IU/mL)¹	139448.20	62210.94
HBeAg	Positive	Positive
ALT (U/L)¹	52	47
HBV DNA (log IU/mL)¹	9.1	9.1
Direct sequencing of infected HBV¹
BCP (nt1762; A:T/nt1764; G:A)	T/G	T/A
Precore stop mutation (nt1896; G:A)	G	G

¹Values at the initiation of tenofovir alafenamide fumarate treatment.

ALT: Alanine aminotransferase; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; HBV: Hepatitis B virus; BCP: Basal core promoter.

Citation: Yamada N, Igarashi H, Murayama A, Suzuki M, Yasuda K, Saito M, Isogawa M, Kato T. Deep sequencing analysis of hepatitis B virus in patients with incomplete response to tenofovir alafenamide fumarate treatment. World J Hepatol 2025; 17(5): 104519
URL: https://www.wjgnet.com/1948-5182/full/v17/i5/104519.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i5.104519