Comparative prognostic performance of staging systems for hepatocellular carcinoma: Evidence from a Vietnamese cohort study

Table 4 Comparison of prognostic and calibration performance of scoring systems at 12 months and 36 months after initial treatment

Score	Time in months	C-index	AUC	χ2	HL P value	LRT P value	AIC	Mean error	90% quantile
BCLC	12	0.769	0.815	254.43	< 0.05	< 10-46	3024.30	0.063	0.280
	36	0.765	0.838	1280.44	< 0.05	< 10-46	2774.41	0.072	0.128
HKLC_9	12	0.794	0.834	451.70	< 0.05	< 10-53	2992.47	0.103	0.183
	36	0.798	0.859	7218.33	< 0.05	< 10-51	2750.78	0.104	0.141
HKLC_5	12	0.793	0.830	372.81	< 0.05	< 10-51	3002.21	0.116	0.175
	36	0.795	0.859	4017.61	< 0.05	< 10-50	2758.09	0.102	0.166
CLIP	12	0.756	0.792	379.93	< 0.05	< 10-49	3010.61	0.068	0.128
	36	0.749	0.809	2490.52	< 0.05	< 10-44	2785.58	0.002	0.005
ITA.LI.CA	12	0.757	0.795	300.31	< 0.05	< 10-45	3025.01	0.067	0.119
	36	0.764	0.814	1741.14	< 0.05	< 10-44	2786.67	0.057	0.074
JIS	12	0.683	0.712	221.52	< 0.05	< 10-25	3116.60	0.064	0.118
	36	0.683	0.721	765.66	< 0.05	< 10-25	2871.86	0.008	0.018
Tokyo	12	0.748	0.781	293.75	< 0.05	< 10-41	3045.51	0.063	0.118
	36	0.755	0.811	1733.23	< 0.05	< 10-41	2797.68	0.010	0.024
MESIAH_GROUP	12	0.739	0.765	242.39	< 0.05	< 10-34	3078.19	0.095	0.234
	36	0.744	0.802	968.24	< 0.05	< 10-38	2812.91	0.143	0.214

C-index: Concordance index; AUC: Area under the curve; HL: Hosmer-Lemeshow test; LRT: Likelihood ratio test; AIC: Akaike information criterion; BCLC: Barcelona Clinic Liver Cancer; HKLC: Hong Kong Liver Cancer; CLIP: Cancer of the Liver Italian Program; ITA.LI.CA: Italian Liver Cancer; JIS: Japan Integrated staging; MESIAH: Model to estimate survival in ambulatory hepatocellular carcinoma patients.