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©The Author(s) 2025.
World J Hepatol. May 27, 2025; 17(5): 104041
Published online May 27, 2025. doi: 10.4254/wjh.v17.i5.104041
Published online May 27, 2025. doi: 10.4254/wjh.v17.i5.104041
Table 2 Univariate and multivariate Cox regression analysis of prognostic factors in the entire cohort and hepatitis B virus-hepatitis C virus infection status subgroups
Variables | Univariate HR (95%CI) | Univariate P | Multivariate HR (95%CI) | Multivariate P value |
Demographic features | ||||
Sex | 1.208 | 0.243 | ||
Age | 1.001 | 0.851 | ||
Clinical features | ||||
Tumor size | 1.130 | < 0.001 | 1.059 (1.024-1.094) | 0.001 |
Tumor number | ||||
1 | < 0.001 | |||
2 | 0.426 | < 0.001 | ||
≥ 3 | 0.407 | < 0.001 | ||
Ruptured tumor | 3.233 | < 0.001 | ||
Solid tumor | 0.342 | < 0.001 | ||
Intrahepatic vascular invasion | 3.295 | 0.001 | ||
Extrahepatic vascular invasion | 9.860 | 0.023 | ||
Portal thrombosis | 4.305 | < 0.001 | 1.905 (1.393-2.608) | < 0.001 |
Metastasis | 1.493 | < 0.001 | 1.270 (1.069-1.509) | 0.007 |
Ascites | 3.406 | < 0.001 | 1.560 (1.166-2.084) | 0.003 |
Portal hypertension | 1.316 | 0.036 | ||
Cirrhosis | 1.938 | < 0.001 | ||
ECOG score | 3.731 | < 0.001 | 2.801 (2.308-3.401) | < 0.001 |
HBV-HCV infection status | 0.002 | |||
HCV | 0.571 | < 0.001 | ||
Non-B-non-C | 0.589 | 0.001 | ||
Co-infected | 0.818 | 0.611 | ||
Laboratory examinations | ||||
AFP | 1.001 | < 0.001 | 1.000 (1.000-1.000) | 0.020 |
ALT | 1.000 | 0.538 | ||
AST | 1.002 | < 0.001 | 1.001 (1.000-1.002) | 0.021 |
Albumin | 0.917 | < 0.001 | 0.956 (0.936-0.977) | < 0.001 |
PT | 0.982 | < 0.001 | ||
INR | 0.923 | 0.632 | ||
Platelet count | 1.003 | < 0.001 | ||
Total bilirubin | 1.005 | < 0.001 | ||
Creatinine | 1.003 | 0.113 | ||
Treatment | ||||
RFA/WMA | < 0.001 | |||
Surgery | 0.064 | < 0.001 | ||
TACE | 0.051 | < 0.001 | ||
Chemotherapy | 0.123 | < 0.001 | ||
Palliative care | 0.119 | < 0.001 |
- Citation: Mai-Phan TA, Nguyen TK, Pham TN, Tran MQ, Le KL. Comparative prognostic performance of staging systems for hepatocellular carcinoma: Evidence from a Vietnamese cohort study. World J Hepatol 2025; 17(5): 104041
- URL: https://www.wjgnet.com/1948-5182/full/v17/i5/104041.htm
- DOI: https://dx.doi.org/10.4254/wjh.v17.i5.104041