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©The Author(s) 2025.
World J Hepatol. May 27, 2025; 17(5): 103852
Published online May 27, 2025. doi: 10.4254/wjh.v17.i5.103852
Published online May 27, 2025. doi: 10.4254/wjh.v17.i5.103852
Table 1 Baseline demographic characteristics, n (%)
Baseline characteristics | Overall population (n = 8191) | Patterns of weight change1 | P value | |||
Stabilizing non-obesity (n = 4565) | Obesity to non-obesity (n = 491) | Non-obesity to obesity (n = 1348) | Stabilizing obesity (n = 1787) | |||
Age (year) | 55.49 (0.22) | 55.49 (0.29) | 59.40 (0.75) | 52.75 (0.42) | 56.53 (0.31) | < 0.0001 |
Gender | 0.0003 | |||||
Male | 4036 (48.72) | 2346 (48.60) | 282 (57.10) | 541 (43.28) | 867 (50.97) | |
Women | 4155 (51.28) | 2219 (51.40) | 209 (42.90) | 807 (56.72) | 920 (49.03) | |
Race | < 0.0001 | |||||
Non-Hispanic White | 3777 (73.05) | 2184 (74.81) | 219 (72.59) | 540 (66.61) | 834 (73.30) | |
Non-Hispanic Black | 1568 (9.19) | 720 (7.22) | 99 (9.87) | 326 (12.80) | 423 (11.58) | |
Mexican | 1134 (6.49) | 529 (5.10) | 94 (8.87) | 233 (9.53) | 278 (7.30) | |
Other Hispanics and mestizos | 1712 (11.27) | 1132 (12.87) | 79 (8.66) | 249 (11.06) | 252 (7.83) | |
Marital status | 0.0197 | |||||
Married | 4840 (64.84) | 2783 (66.83) | 277 (63.84) | 759 (61.31) | 1021 (62.45) | |
Else | 3348 (35.16) | 1782 (33.17) | 214 (36.16) | 588 (38.69) | 764 (37.55) | |
Mean body mass index (kg/m2) | ||||||
25 years old | 24.16 (0.07) | 22.37 (0.06) | 26.24 (0.30) | 24.07 (0.14) | 28.432 (0.16) | < 0.0001 |
10 years before baseline | 27.53 (0.11) | 24.13 (0.06) | 32.77 (0.13) | 26.97 (0.08) | 35.64 (0.18) | < 0.0001 |
Baseline | 29.16 (0.12) | 25.02 (0.07) | 27.56 (0.13) | 33.53 (0.12) | 37.23 (0.19) | < 0.0001 |
Net weight change (kg) | 4.56 (0.20) | 2.50 (0.13) | -14.84 (0.49) | 18.34 (0.41) | 4.61 (0.47) | < 0.0001 |
Level of education3 | < 0.0001 | |||||
High school dropout or below | 2110 (16.56) | 1112 (15.45) | 153 (20.13) | 370 (18.82) | 475 (16.95) | |
Graduate from high school | 1868 (22.34) | 1030 (21.77) | 118 (22.59) | 313 (24.08) | 407 (22.50) | |
Drop out of college | 2203 (29.43) | 1107 (25.95) | 147 (35.14) | 413 (33.00) | 536 (34.57) | |
University graduate or above | 2003 (31.66) | 1311 (36.83) | 73 (22.14) | 251 (24.09) | 368 (25.98) | |
Household income poverty ratio3 | < 0.0001 | |||||
0-1.0 | 1434 (11.48) | 742 (10.41) | 104 (15.60) | 265 (13.44) | 323 (11.85) | |
1.1-3.0 | 3119 (33.95) | 1659 (31.50) | 220 (42.09) | 518 (36.14) | 722 (36.82) | |
> 3.0 | 2982 (54.57) | 1797 (58.09) | 123 (42.32) | 444 (50.42) | 618 (51.33) | |
Smoking status3 | < 0.0001 | |||||
Never smoked | 4243 (51.75) | 2356 (51.87) | 222 (45.38) | 717 (51.10) | 948 (53.48) | |
Cessation | 2373 (29.91) | 1264 (28.02) | 153 (33.58) | 379 (29.91) | 577 (34.00) | |
Smoking | 1569 (18.34) | 941 (20.11) | 115 (21.05) | 251 (18.99) | 262 (12.52) | |
Drinking status3 | 0.0037 | |||||
Never | 1068 (10.63) | 571 (9.76) | 73 (14.25) | 179 (10.96) | 245 (11.73) | |
Cessation | 1134 (12.95) | 567 (11.44) | 62 (13.69) | 189 (13.61) | 316 (16.18) | |
Drinking | 5416 (76.43) | 3077 (78.80) | 325 (72.06) | 884 (75.44) | 1130 (72.10) | |
Sports | < 0.0001 | |||||
Low intensity | 5424 (62.68) | 2921 (59.41) | 337 (65.11) | 907 (63.90) | 1259 (69.78) | |
Medium intensity | 1119 (15.71) | 680 (17.12) | 63 (16.31) | 169 (15.46) | 207 (12.01) | |
High intensity | 1648 (21.62) | 964 (23.47) | 91 (18.57) | 272 (20.64) | 321 (18.21) | |
History of the tumor | 0.0001 | |||||
None | 7222 (87.32) | 4018 (87.01) | 408 (82.00) | 1236 (91.74) | 1560 (86.15) | |
Have | 962 (12.68) | 543 (12.99) | 81 (18.00) | 112 (8.26) | 226 (13.85) | |
History of diabetes | < 0.0001 | |||||
None | 6667 (87.64) | 4071 (94.05) | 313 (71.79) | 1094 (87.10) | 1189 (74.57) | |
Have | 1276 (12.36) | 401 (5.95) | 158 (28.21) | 205 (12.90) | 512 (25.43) | |
History of cardiovascular disease | < 0.0001 | |||||
None | 4195 (55.18) | 2771 (65.39) | 189 (40.24) | 638 (49.15) | 597 (36.40) | |
Have | 3996 (44.82) | 1794 (34.61) | 302 (59.76) | 710 (50.85) | 1190 (63.60) |
- Citation: Wang JP, Wang JY, Sun PQ, Wang XW, Yuan ZT, Cao Q, Pan SM, Jiang YY. Association between weight fluctuation and the risk of metabolic dysfunction-associated steatotic liver disease. World J Hepatol 2025; 17(5): 103852
- URL: https://www.wjgnet.com/1948-5182/full/v17/i5/103852.htm
- DOI: https://dx.doi.org/10.4254/wjh.v17.i5.103852