Association of Life’s Essential 8 and Life’s Simple 7 with metabolic-associated fatty liver disease in the United States

Table 2 Association of Life’s Essential 8 and Life’s Simple 7 with metabolic-associated fatty liver disease (weighted)¹

		Model 0	P value	Model 1	P value	Model 2	P value	Model 3	P value
		OR (95%CI)		OR (95%CI)		OR (95%CI)		OR (95%CI)
LE8 (per 10)	Continuous	0.51 (0.46-0.56)	< 0.001	0.53 (0.48-0.58)	< 0.001	0.5 (0.43-0.59)	< 0.001	0.51 (0.41-0.64)	0.006
LE8 group
	Low	Reference		Reference		Reference		Reference
	Moderate	0.28 (0.19-0.42)	< 0.001	0.30 (0.20-0.45)	< 0.001	0.27 (0.13-0.59)	0.018	0.29 (0.13-0.65)	0.022
	High	0.05 (0.03-0.07)	< 0.001	0.06 (0.04-0.09)	< 0.001	0.05 (0.02-0.14)	0.006	0.06 (0.02-0.15)	0.007
	P for trend		< 0.001		< 0.001		< 0.001		0.001
LS7	Continuous	0.62 (0.57-0.68)	< 0.001	0.63 (0.58-0.68)	< 0.001	0.61 (0.53-0.70)	0.001	0.62 (0.50-0.76)	0.01
LS7 group
	Inadequate	Reference		Reference		Reference		Reference
	Average	0.31 (0.22-0.44)	< 0.001	0.32 (0.22-0.45)	< 0.001	0.29 (0.14-0.60)	0.018	0.32 (0.14- 0.74)	0.028
	Optimal	0.04 (0.02-0.09)	< 0.001	0.05 (0.03-0.10)	< 0.001	0.05 (0.01, 0.18)	0.011	0.05 (0.01- 0.22)	0.013
	P for trend		< 0.001		< 0.001		0.003		0.004

¹Model 0 Unadjusted. Model 1 Adjusted for age and sex.

Model 2 Further adjusted for ethnicity, education, marital status, poverty-income ratio, and alcohol status. Model 3 Further adjusted for comorbid conditions (diabetes, kidney failure, kidney stones, heart failure, stroke, hepatopathy, rheumatoid arthritis, and cancer).

LE8: Life’s Essential 8; LS7: Life’s Simple 7.