Clinical features and prognosis of drug-induced liver injury in patients with non-alcoholic fatty liver

Table 3 Possible hepatotoxic drugs in the study cohort

Medication history	DILI	DILI + NAFL
Chinese medicine, proprietary Chinese medicine	Lianhua Qingdian (Mianma Guanzhong)	Gynostemma Total Glycosides Tablets
	Warm Stomach Shule (Astragalus, Yanhusuo)	Gastrointestinal An
	Danlu Tongdu Tablet (Salvia miltiorrhiza, Astragalus membranaceus, Yanhuosuo)	Kun Bao Wan (Prepared He Shou Wu, Astragalus)
	Xian Ling Bone Fructus Capsule (Radix et Rhizoma Polygoni Multiflori, Salviae Miltiorrhizae)	Uterine Blood Ning
	Milk fetish elimination (Poria cocos)	Shen Xiang Shu Yu (Yan Hu Suo, Chai Hu)
	Lingbao Heart Protecting Tablets (Salvia miltiorrhiza)	Gentiana Macrophyllae Capsules
	Nourishing Heart Tablets (Astragalus, Yanhusuo, Salvia Miltiorrhiza)	Panax ginseng powder
	Golden Chamber Kidney Qi Pills (Zelda)	Bailemian (Containing Shouwu Teng)
	Rejuvenation (Zedoary, Shouwu Teng)	Dan Hong (Salvia miltiorrhiza)
	Bailomian (Shouwu Teng)	Moistening Dryness and Relieving Itching Capsule (He Shouwu, Prepared He Shouwu)
	Zidan Blood Capsules (Panax ginseng saponin, Radix et Rhizoma Ginseng)	Salvia divinorum Drops (Salvia divinorum)
	Bai Cao Yishou Tea (Astragalus)	Exquisite Yin Qiao Tablets
	Ganoderma Lucidum Spore Powder	Tongxin Nourishing Heart (Prepared He Shouwu)
	Brain Heart (Astragalus, Salvia Miltiorrhiza, Scorpion, Leech)	Di Ao Heart Blood Kang
	Jia Wei Yi Puan (Mentha piperita, Chai Hu)	Mudan Granules (Huang's, Yanhuisuo, Panax ginseng, Paeonia lactiflora, Paeonia lactiflora, Salvia miltiorrhiza, Chuan Gong, Safflower, Sumac, Chickweed)
	Antelope Clear Lung Capsule (Smallpox Powder, Mint)	Xintong Oral Liquid (Astragalus, He Shouwu, Salvia Miltiorrhiza)
	Jumbo Pills (Clove)	Lipitor (Zedoary)
	Osteoporosis (Astragalus, Danshen)	Niu Huang Blood Pressure Reducing Pill (Astragalus, Mentha piperita)
	Deer Chuan Activating Capsule (Scorpion, Yanhuisuo)	Dendrobium Nightshade Pill
	Stomach-clearing Huanglian Pill (Smallpox Powder, Astragalus)	Gynostemma Capsules (Radix et Rhizoma Ginseng, Radix et Rhizoma Serpentae, Radix et Rhizoma Pinelliae, Radix et Rhizoma Bitterwood, Pericarpium Laminariae, Icicle, Menthol)
	Pu Shen Capsule (He Shou Wu, Pu Huang)	Sanwu Capsule (Shouwu Teng)
	Huo Xiang Zheng Qi Capsule (Semen Armeniacae)	Lianhua Qingdian (Mianma Guanzhong)
	Nourishing Blood and Nourishing Kidney Pill (Prepared He Shouwu)	Wind-dispersing and pain-relieving granules (Chai Hu)
	Nourishing the Heart by Nourishing the Veins (Prepared He Shouwu)	Blue Scutellaria Oral Liquid (Astragalus)
	Compound Danshen Drop Pills (Salvia divinorum)	Shu Shen Ling (Shou Wu Teng)
	Tangerine Red Phlegm and Cough Liquid (Semen Huperzia)	Nourishing Blood and Clearing Brain (Yanhuosuo)
	Gui Zhi Fu Ling Capsules	Compound Rheumatism Ning
	Betel Nut Si-Xie Tablet	Inibi Tablets
	Shuanghuanglian (Astragalus)	Inibalance Pills (Roasted Astragalus, Chai Hu)
	Hematoxylin (Chai Hu)	Qingdianxie Tablet (Smallpox Powder, Astragalus, Chai Hu)
	Pu Shen Capsule (He Shou Wu, Ze Xie)	Dong Ling Cao Tablet
	Ginkgo Biloba Ketone Ester Dispersible Tablets	Tongxuanliang Pill (Semixia, Astragalus)
	Muxiang Shunqi	Tiger Balm Tablets
	Liu Wei Di Huang Pill	Gui Long Tendon & Bone Ning (Salvia miltiorrhiza)
	Yanshou Tablets	Golden Throat Pills (Acacia Pi)
	Heze	Zachong Thirteen Flavor Pills (Clove)
	Shouwu Teng	Shu Brain Xin Drops
	Lei Gong Teng	Xihuang Pills
	Saffron	Zijin Long Tablets (Astragalus and Salvia Miltiorrhiza)
	Zedoary	Bornin (Roasted Astragalus)
	He Shou Wu	Zhen's Fu Zheng (Astragalus)
		Pingxiao Capsules
		Yin Qiao Tablet
		Pientzehuang Tablet
		Formula: (1) Fried Sophora japonica, Fried Bitter Almond, Pueraria Mirifica, Paeoniae Alba, Cortex Pseudostellariae, Peony Peel, Roasted Licorice, Ascorbic Acid, Gypsum, Ephedra, Cinnamon Branches, Cicada Shell
		(2) Forsythia, Rhizoma Atractylodis Macrocephalae, Roasted Epimedium, Cinnamon Branches, Folium Artemisiae, Hei Shun Piece, Jujubes, Ginger, Sequelae, Wine Huang Cen, Zingiber officinale, Burnt Hawthorn, Taraxacum officinale
		(3) Lycium barbarum, licorice, Radix Fructus Fructus, Fructus Chrysanthemi, Semen Coicis, Mulberry Leaf, Gardenia Jasminoides, Oyster, Cassia Seed, Lotus Seed
		(4) Gypsum, Zhi Mu, Radix et Rhizoma Ginseng, Pollen, Poria cocos, Morus alba, Zhe Bei, Xuan Shen, Ophiopogon, Chrysanthemum, Radix et Rhizoma Sheng Di
		Salvia miltiorrhiza
		Radix Bupleurum Chinense
		He Shou Wu
		Psoralea rubra
		Senna
		Xiaku Cao Cao Cream
		Deer Whip Cream
		Ginseng
		Lei Gong Teng
		Scorpion
		Leech
		Zezhi diarrhea (used in TCM)
		Acanthopanax Senticosus
		Dragon's blood exhaust
		Dandelion
Western medicine
Anti-infective drugs	Cefoperazone sodium sulbactam sodium, furotoxin, levofloxacin, azithromycin, amoxicillin, clindamycin, isoniazid, rifampicin, streptomycin, bispyrazinamide	Levofloxacin, furotoxin, amoxicillin, itraconazole, roxithromycin
Nonsteroidal anti-inflammatory drug	Loxoprofen, Lovenox Extended-Release Tablets, Acetaminophen	Saxifrage, aminopyrine, aminocaprofen tablets, cotrimoxazole, nimesulide
Cardiovascular drugs	Fluvastatin, Rosuvastatin, Propafenone	Amlodipine benzenesulfonate, aliskatam, nifedipine, irbesartan hydrochlorothiazide, valsartan, felodipine, trandolazine, atorvastatin, simvastatin, acyclovir, atorvastatin, simvastatin, acyclovir, propafenone
Antitumor drugs
Antiulcer drug	Omeprazole (antifungal agent)	Lansoprazole, Rabeprazole
Psychotropic drugs		Flunarizine hydrochloride, betahistine mesylate, clonazepam, trazodone
Hormone antagonists		Letrozole, exemestane, tamoxifen citrate
Other	Mothballs (naphthalene or p-dichlorobenzene), toluene	Glucosamine, analgesic injections (ketorolac tromethamine, resorcinol), eteplirisone hydrochloride tablets, methimazole
Dietary supplement	Amway Health Care, Herbalife, Jens United States	Bovine Vitamin Tablets, Enzymes, Glutamine

TCM: Traditional Chinese medicine; DILI: Drug-induced liver injury; NAFL: Nonalcoholic fatty liver.