Modern ultrasound techniques for diagnosing liver steatosis and fibrosis: A systematic review with a focus on biopsy comparison

Table 12 QUADAS-2 evaluation results

Ref.	Risk of bias by domain				Applicability by domain
	D1	D2	D3	D4	D1	D2	D3
Aksakal et al[20]	Low	Low	Low	Low	Low	Low	Low
Alcantara-Diaz et al[21]	High	Uncertain	Uncertain	Low	High	Low	Low
Atzori et al[22]	Low	Low	Low	Low	Low	Low	Low
Cassinotto et al[23]	Low	Low	Low	Low	Low	Low	Low
Damjanovska et al[24]	High	Uncertain	Uncertain	High	Low	Low	Low
Fang et al[25]	Low	Uncertain	Uncertain	Low	Low	Low	Low
Garcovich et al[26]	Low	Low	Low	Low	Low	Low	Low
Gatos et al[27]	Low	Low	Low	Low	Low	Low	Low
Hsu et al[56]	Low	Low	Low	Low	Low	Low	Low
Imajo et al[66]	Low	Low	Low	Low	Low	Low	Low
Jocius et al[28]	Low	Uncertain	Uncertain	Low	Low	Low	Low
Kavak et al[29]	Uncertain	Uncertain	Uncertain	Uncertain	Low	Low	Low
Kim et al[67]	Low	Low	Low	Low	Low	Low	Low
Kjaergaard et al[57]	Low	Low	Low	Low	Low	Low	Low
Kuroda et al[58]	Low	Low	Low	Low	Low	Low	Low
Laroia et al[30]	Low	Low	Low	Low	Low	Low	Low
Lee et al[31]	Low	Low	Low	Low	Low	Low	Low
Liu et al[59]	Low	Uncertain	Uncertain	Low	Low	Low	Low
Manesis et al[32]	Uncertain	Uncertain	Uncertain	Low	Low	Low	Low
Martonik et al[33]	Low	Low	Low	Low	Low	Low	Low
Mendoza et al[34]	Low	Uncertain	Uncertain	Low	Low	Low	Low
Mikolasevic et al[35]	Low	Uncertain	Uncertain	Low	Low	Low	Low
Nogami et al[36]	Uncertain	Low	Low	Low	Low	Low	Low
Ogino et al[37]	Low	Low	Low	Uncertain	Low	Low	Low
Paisant et al[38]	Low	Low	Low	Low	Low	Low	Low
Patidar et al[39]	Low	Low	Low	Uncertain	Low	Low	Low
Prieto Ortiz et al[68]	High	Uncertain	Uncertain	High	High	High	High
Qu et al[60]	Low	Low	Low	Low	Low	Low	Low
Roccarina et al[40]	Low	Low	Low	Low	Low	Low	Low
Saadi et al[41]	Low	Low	Low	Low	Low	Low	Low
Seyrek et al[42]	Low	Low	Low	Low	Low	Low	Low
Sharpton et al[43]	Low	Low	Low	Low	Low	Low	Low
Soh et al[44]	Low	Uncertain	Uncertain	Low	Low	Low	Low
Song et al[45]	Low	Low	Low	Low	Low	Low	Low
Taibbi et al[46]	High	Low	Low	High	Low	Low	Low
Wang et al[47]	High	Uncertain	Uncertain	Low	Low	Low	Low
Wang et al[48]	Uncertain	Low	Low	Uncertain	Low	Low	Low
Wang et al[49]	Low	Low	Low	Low	Low	Low	Low
Welman et al[63]	High	Low	Low	High	Low	Low	Low
Yamaoka et al[54]	Low	Low	Low	Low	Low	Low	Low
Yan et al[69]	Low	Low	Low	Low	Low	Low	Low
Yang et al[50]	High	Low	Low	Uncertain	Low	Low	Low
Yang et al[51]	High	Low	Low	Uncertain	Low	Low	Low
Yazdani et al[61]	Low	Low	Low	Low	Low	Low	Low
Yoo et al[53]	High	Low	Low	Uncertain	Low	Low	Low
Yoo et al[52]	High	Low	Low	Uncertain	Low	Low	Low
Yu et al[62]	Low	Low	Low	Low	Low	Low	Low
Zhang et al[70]	Low	Low	Low	Low	Low	Low	Low
Zhao et al[65]	Low	Low	Low	Low	Low	Low	Low
Zhou et al[64]	Low	Low	Low	Low	Low	Low	Low
Zougmoré et al[55]	High	Low	Low	Low	Low	Low	Low