Integrated serum metabolomics reveal molecular mechanism of Xietu Hemu prescription on metabolic dysfunction-associated steatotic liver disease-related obesity

Figure 5 The correlation assessment of Xietu Hemu prescription and obesity. A: Composition of Xietu Hemu prescription (XHP) by “JUN-CHEN-ZUO-SHI”; B: The strength of the correlation between each XHP botanical drug with obesity was obtained from the literature search; C: Number of exclusive metabolites or overlap metabolites of each botanical drug in XHP; D: The structure of representative metabolites in XHP serum; E: Network of XHP serum metabolites with related targets; F: Protein-protein interaction network of the targets in E; G: Model decomposition of F into 7 sub-networks; H-K: Functional analysis of the sub-networks. H and I are the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of cluster 1, while J and K are the KEGG pathway and GO enrichment analyses of cluster 2. XHP: BP: Biological processes; CC: Cellular components; MF: Molecular functions.