Hepatic enhancement and signal intensity analysis on magnetic resonance imaging as prognostic biomarkers in advanced chronic liver disease

doi:10.4254/wjh.v17.i12.111418

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Hepatol. Dec 27, 2025; 17(12): 111418
Published online Dec 27, 2025. doi: 10.4254/wjh.v17.i12.111418

Table 7 Global hepatic enhancement variation by clinical outcomes across the whole cohort and subgroups

Cohort	Outcome	Group	Mean HE ± SD	t (df)	P value	q value	Cohen’s d
Full cohort (n = 100)	HCC development	No HCC	87.48 ± 37.86	-1.662 (98)	0.100	0.100	0.384
	HCC development	HCC	102 ± 37.71	-1.662 (98)	0.100	0.100	0.384
	Decompensation	No decompensation	100.87 ± 34.30	3.526 (98)	0.001^a	0.003^a	0.717
	Decompensation	Decompensation	74.48 ± 39.07	3.526 (98)	0.001^a	0.003^a	0.717
	Mortality	Survivor	94.34 ± 36.65	2.231 (98)	0.028^a	0.042^a	0.625
	Mortality	Dead	69.52 ± 42.47	2.231 (98)	0.028^a	0.042^a	0.625
Non-HCC (n = 80)	HCC development	No HCC	81.12 ± 37.64	-1.448 (78)	0.152	0.152	0.379
	HCC development	HCC	95 ± 35.45	-1.448 (78)	0.152	0.152	0.379
	Decompensation	No decompensation	93.66 ± 33.63	2.478 (78)	0.015^a	0.026^a	0.552
	Decompensation	Decompensation	73.50 ± 39.16	2.478 (78)	0.015^a	0.026^a	0.552
	Mortality	Survivor	95.26 ± 37.02	2.622 (78)	0.011^a	0.033^a	0.941
	Mortality	Dead	63 ± 31.29	2.622 (78)	0.011^a	0.033^a	0.941
Viral cirrhosis (n = 53)	HCC development	No HCC	98.44 ± 37.70	-1.713 (51)	0.093	0.140	0.517
	HCC development	HCC	116.69 ± 32.74	-1.713 (51)	0.093	0.140	0.517
	Decompensation	No decompensation	105.57 ± 34.89	1.293 (51)	0.202	0.303	0.368
	Decompensation	Decompensation	91.56 ± 39.24	1.293 (51)	0.202	0.303	0.368
	Mortality	Survivor	105.99 ± 34.54	1.181 (51)	0.243	0.243	0.448
	Mortality	Dead	83.44 ± 62.18	1.181 (51)	0.243	0.243	0.448
Alcoholic cirrhosis (n = 41)	HCC development	No HCC	77.57 ± 33.92	0.523 (39)	0.604	0.604	0.218
	HCC development	HCC	70.78 ± 28.05	0.523 (39)	0.604	0.604	0.218
	Decompensation	No decompensation	94.49 ± 27.14	5.523 (39)	0.001^a	0.003^a	1.095
	Decompensation	Decompensation	61.57 ± 32.72	5.523 (39)	0.001^a	0.003^a	1.095
	Mortality	Survivor	79.88 ± 32.01	1.357 (39)	0.182	0.273	0.505
	Mortality	Dead	63.33 ± 33.40	1.357 (39)	0.182	0.273	0.505

^aP/q ≤ 0.05.

Values are Spearman’s q-value after false discovery rate-adjusted results (Benjamini-Hochberg procedure). Cohen’s d: Effect size; df: Degrees of freedom; HCC: Hepatocellular carcinoma; HE: Hepatic enhancement; SD: Standard deviation; t: t statistic.

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Citation: Stanciu BI, Iojiban M, Morariu-Barb A, Caraiani C, Procopet B, Stefanescu H, Lupsor-Platon M. Hepatic enhancement and signal intensity analysis on magnetic resonance imaging as prognostic biomarkers in advanced chronic liver disease. World J Hepatol 2025; 17(12): 111418
URL: https://www.wjgnet.com/1948-5182/full/v17/i12/111418.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i12.111418

Stanciu BI, Iojiban M, Morariu-Barb A, Caraiani C, Procopet B, Stefanescu H, Lupsor-Platon M. Hepatic enhancement and signal intensity analysis on magnetic resonance imaging as prognostic biomarkers in advanced chronic liver disease. World J Hepatol 2025; 17(12): 111418 [PMID: 41479507 DOI: 10.4254/wjh.v17.i12.111418]

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