Hepatic enhancement and signal intensity analysis on magnetic resonance imaging as prognostic biomarkers in advanced chronic liver disease

doi:10.4254/wjh.v17.i12.111418

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Hepatol. Dec 27, 2025; 17(12): 111418
Published online Dec 27, 2025. doi: 10.4254/wjh.v17.i12.111418

Table 6 Correlations among hepatic enhancement, liver stiffness, and hepatic venous-portal gradient across the entire cohort and subgroups

Cohort	Region	Liver stiffness (ρ/q)	HVPG (ρ/q)
Full cohort (n = 100)	HE segment VI	-0.428/0.002^a	-0.345/0.049^a
	HE segment VIII	-0.503/0.001^a	-0.389/0.042^a
	HE caudate lobe	-0.477/0.001^a	-0.362/0.049^a
	HE segment III	-0.418/0.002^a	-0.232/0.127
	Global HE	-0.470/0.001^a	-0.340/0.049^a
Non-HCC (n = 80)	HE segment VI	-0.358/0.014^a	-0.200/0.261
	HE segment VIII	-0.470/0.003^a	-0.235/0.255
	HE caudate lobe	-0.447/0.003^a	-0.169/0.261
	HE segment III	-0.399/0.008^a	-0.049/0.416
	Global HE	-0.430/0.003^a	-0.167/0.261
Viral (n = 53)	HE segment VI	-0.211/0.127	0.160/0.492
	HE segment VIII	-0.328/0.059	-0.081/0.492
	HE caudate lobe	-0.217/0.120	-0.042/0.492
	HE segment III	-0.323/0.059	0.071/0.492
	Global HE	-0.286/0.120	0.093/0.492
Alcoholic (n = 41)	HE segment VI	-0.513/0.022^a	-0.552/0.061
	HE segment VIII	-0.604/0.020^a	-0.533/0.061
	HE caudate lobe	-0.533/0.020^a	-0.508/0.061
	HE segment III	-0.455/0.038^a	-0.433/0.092
	Global HE	-0.552/0.020^a	-0.524/0.061

^aq ≤ 0.05.

Values are Spearman’s ρ/q-value after false discovery rate-adjusted results (Benjamini-Hochberg procedure). Hepatic venous-portal gradient analyses restricted to patients with invasive measurements (n = 26). HCC: Hepatocellular carcinoma; HE: Hepatic enhnancement; HVPG: Hepatic venous-portal gradient; ρ: Correlation coefficient.

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Citation: Stanciu BI, Iojiban M, Morariu-Barb A, Caraiani C, Procopet B, Stefanescu H, Lupsor-Platon M. Hepatic enhancement and signal intensity analysis on magnetic resonance imaging as prognostic biomarkers in advanced chronic liver disease. World J Hepatol 2025; 17(12): 111418
URL: https://www.wjgnet.com/1948-5182/full/v17/i12/111418.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i12.111418

Stanciu BI, Iojiban M, Morariu-Barb A, Caraiani C, Procopet B, Stefanescu H, Lupsor-Platon M. Hepatic enhancement and signal intensity analysis on magnetic resonance imaging as prognostic biomarkers in advanced chronic liver disease. World J Hepatol 2025; 17(12): 111418 [PMID: 41479507 DOI: 10.4254/wjh.v17.i12.111418]

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