Hepatic enhancement and signal intensity analysis on magnetic resonance imaging as prognostic biomarkers in advanced chronic liver disease

doi:10.4254/wjh.v17.i12.111418

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Hepatol. Dec 27, 2025; 17(12): 111418
Published online Dec 27, 2025. doi: 10.4254/wjh.v17.i12.111418

Table 5 Correlations among hepatic enhancement, Functional Liver Imaging Score, and clinical scores across the entire cohort and subgroups

Cohort	Region	FLIS	Child-Pugh	MELD 3.0	ALBI	FIB-4
Full cohort (n = 100)	HE segment VI	0.819^a	-0.611^a	-0.683^a	-0.624^a	-0.306^a
	HE segment VIII	0.718^a	-0.469^a	-0.584^a	-0.490^a	-0.300^a
	HE caudate lobe	0.765^a	-0.592^a	-0.634^a	-0.590^a	-0.312^a
	HE segment III	0.741^a	-0.580^a	-0.625^a	-0.579^a	-0.253^a
	Global HE	0.797^a	-0.589^a	-0.658^a	-0.599^a	-0.308^a
Non-HCC (n = 80)	HE segment VI	0.858^a	-0.616^a	-0.649^a	-0.624^a	-0.301^a
	HE segment VIII	0.716^a	-0.475^a	-0.551^a	-0.463^a	-0.278^a
	HE caudate lobe	0.790^a	-0.601^a	-0.599^a	-0.576^a	-0.302^a
	HE segment III	0.761^a	-0.582^a	-0.583^a	-0.568^a	-0.265^a
	Global HE	0.820^a	-0.596^a	-0.622^a	-0.591^a	-0.301^a
Viral (n = 53)	HE segment VI	0.656^a	-0.423^a	-0.574^a	-0.444^a	-0.287^a
	HE segment VIII	0.589^a	-0.320^a	-0.542^a	-0.410^a	-0.287^a
	HE caudate lobe	0.633^a	-0.456^a	-0.533^a	0.485^a	-0.342^a
	HE segment III	0.610^a	-0.471^a	-0.631^a	-0.530^a	-0.312^a
	Global HE	0.649^a	-0.433^a	-0.594^a	-0.485^a	-0.318^a
Alcoholic (n = 41)	HE segment VI	0.834^a	-0.603^a	-0.611^a	-0.594^a	-0.148 (q = 0.418)
	HE segment VIII	0.714^a	-0.412^a	-0.431^a	-0.396^a	-0.198 (q = 0.269)
	HE caudate lobe	0.739^a	-0.537^a	-0.513^a	-0.476^a	-0.074 (q = 0.682)
	HE segment III	0.707^a	-0.530^a	-0.414^a	-0.458^a	-0.013 (q = 0.936)
	Global HE	0.796^a	-0.546^a	-0.531^a	-0.511^a	-0.123 (q = 0.492)

^aq ≤ 0.05.

Values are Spearman’s ρ/q-value after false discovery rate-adjusted results (Benjamini-Hochberg procedure). ALBI: Albumin-Bilirubin score; FIB-4: Fibrosis-4 Index; FLIS: Functional liver imaging score; HCC: Hepatocellular carcinoma; HE: Hepatic enhancement; MELD 3.0: Model for End-Stage Liver Disease 30.

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Citation: Stanciu BI, Iojiban M, Morariu-Barb A, Caraiani C, Procopet B, Stefanescu H, Lupsor-Platon M. Hepatic enhancement and signal intensity analysis on magnetic resonance imaging as prognostic biomarkers in advanced chronic liver disease. World J Hepatol 2025; 17(12): 111418
URL: https://www.wjgnet.com/1948-5182/full/v17/i12/111418.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i12.111418

Stanciu BI, Iojiban M, Morariu-Barb A, Caraiani C, Procopet B, Stefanescu H, Lupsor-Platon M. Hepatic enhancement and signal intensity analysis on magnetic resonance imaging as prognostic biomarkers in advanced chronic liver disease. World J Hepatol 2025; 17(12): 111418 [PMID: 41479507 DOI: 10.4254/wjh.v17.i12.111418]

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