Targeting sirtuin 1/nuclear factor erythroid 2-related factor 2/tumor necrosis factor-α pathway to modulate hepatic ischemia reperfusion-induced injury

Figure 3 Effect of different doses of aprepitant on hepatic sirtuin 1 western blotting in hepatic ischemia reperfusion-induced liver injury in rats. Results are considered significantly different when P < 0.05. ^aP < 0.05 significantly different from Sham group; ^bP < 0.05 significantly different from Sham/aprepitant 10; ^cP < 0.05 significantly different from hepatic ischemia reperfusion group. APRE5: Aprepitant 5 mg/kg; APRE10: Aprepitant 10 mg/kg; APRE20: Aprepitant 20 mg/kg; HIR: Hepatic ischemia reperfusion; SIRT-1: Sirtuin1.