Targeting sirtuin 1/nuclear factor erythroid 2-related factor 2/tumor necrosis factor-α pathway to modulate hepatic ischemia reperfusion-induced injury

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World Journal of Hepatology

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1948-5182

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World J Hepatol. Dec 27, 2025; 17(12): 110733
Published online Dec 27, 2025. doi: 10.4254/wjh.v17.i12.110733

Table 1 Effect of different doses of aprepitant on survival rate of hepatic ischemia reperfusion injury in rats

Group	Sham	Sham/APRE10	HIR	HIR/APRE5	HIR/APRE10	HIR/APRE20
Survival	100	100	62.5	75	87.5	100

APRE5: Aprepitant 5 mg/kg; APRE10: Aprepitant 10 mg/kg; APRE20: Aprepitant 20 mg/kg; HIR: Hepatic ischemia reperfusion.

Citation: Kelleni MT, Abdelzaher WY, Adly M, Attya ME, Fawzy MA, Ibrahim MA. Targeting sirtuin 1/nuclear factor erythroid 2-related factor 2/tumor necrosis factor-α pathway to modulate hepatic ischemia reperfusion-induced injury. World J Hepatol 2025; 17(12): 110733
URL: https://www.wjgnet.com/1948-5182/full/v17/i12/110733.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i12.110733

Kelleni MT, Abdelzaher WY, Adly M, Attya ME, Fawzy MA, Ibrahim MA. Targeting sirtuin 1/nuclear factor erythroid 2-related factor 2/tumor necrosis factor-α pathway to modulate hepatic ischemia reperfusion-induced injury. World J Hepatol 2025; 17(12): 110733 [PMID: 41479522 DOI: 10.4254/wjh.v17.i12.110733]

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