Molecular biomarkers of sintilimab plus lenvatinib in hepatitis-B-virus-associated hepatocellular carcinoma

Table 2 Univariate and multivariate Cox regression analysis of factors associated with progression-free survival (backward stepwise selection with Wald criteria)

	Number	Univariate HR	P value	Multivariate HR	P value
Tumor number (single/multiple)	18/15	0.33 (0.14-0.78)	0.01	0.31 (0.11-0.85)	0.02
AFP (< 400/≥ 400 ng/mL)	18/15	0.49 (0.22-1.11)	0.09	-	-
CUX1 (wild/mutant)	30/3	0.22 (0.06-0.79)	0.02	-	-
LINC01554 (high/Low)	15/15	0.32 (0.13-0.79)	0.01	0.16 (0.05-0.49)	0.01
WHRN (high/Low)	15/15	0.39 (0.16-0.94)	0.04	-	-
CD4+ Tcm (high/Low)	9/21	0.43 (0.16-1.19)	0.10	0.29 (0.08-0.98)	0.05

HR: Hazard ratio; AFP: Alpha-fetoprotein; CUX1: Cut-like homeobox 1; LINC01554: Long intergenic non-protein coding RNA 01554; WHRN: Whirlin; CD4+ Tcm: CD4+ central memory T cells.