Cytokeratin 18 fragment is associated with steatosis-associated fibrosis estimator score and lipid in patients with steatotic liver disease

doi:10.4254/wjh.v17.i11.110698

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Nov 27, 2025; 17(11): 110698
Published online Nov 27, 2025. doi: 10.4254/wjh.v17.i11.110698

Table 1 Clinical factors, n (%)

Cytokeratin 18 fragment (high: > 260 U/L)		Normal	High	P value	Odds ratio/95%CI
Steatotic liver disease	Metabolic dysfunction and alcohol-related liver disease	35 (36.5)	8 (27.6)	0.37810	1
Steatotic liver disease	Metabolic dysfunction-associated steatotic liver disease	61 (63.5)	21 (72.4)	0.37810	1.507/0.726-3.129
Sex	Woman	53 (55.2)	14 (48.3)	0.51180	1
Sex	Man	43 (44.8)	15 (51.7)	0.51180	1.321/0.575-3.035
Age	n	96	29	0.20098	0.975/0.943-1.008
	Median	63.0	59.0
	Q1 (25%)	56.5	48.5
	Q3 (75%)	70.0	69.8
Total bilirubin (normal range, 0.3-1.2 mg/dL)	n	96	29	0.70006	1.482/0.591-3.713
	Median	0.80	0.80
	Q1 (25%)	0.60	0.60
	Q3 (75%)	1.00	1.08
Total protein (6.7-8.3 g/dL)	n	96	29	0.00357	4.828/1.653-14.02
	Median	7.40	7.60
	Q1 (25%)	7.05	7.40
	Q3 (75%)	7.60	7.83
Albumin (3.8-5.2 g/dL)	n	96	29	0.59102	1.553/0.532-4.532
	Median	4.30	4.30
	Q1 (25%)	4.00	4.08
	Q3 (75%)	4.50	4.60
PT (70%-130%)	n	96	29	0.31843	0.99/0.966-1.014
	Median	98.10	92.00
	Q1 (25%)	85.80	83.10
	Q3 (75%)	107.70	102.78
PT international normalized ratio (0.9-1.1)	n	96	29	0.29846	2.701/0.069-105.6
	Median	1.010	1.040
	Q1 (25%)	0.970	0.988
	Q3 (75%)	1.075	1.085
Creatinine (M: 0.61-1.04 mg/dL and W: 0.47-0.79 mg/dL)	n	96	29	0.93705	1.322/0.203-8.593
	Median	0.730	0.750
	Q1 (25%)	0.650	0.648
	Q3 (75%)	0.900	0.873
Body mass index	n	96	29	0.07636	1.057/0.977-1.145
	Median	25.01	26.63
	Q1 (25%)	22.41	23.32
	Q3 (75%)	27.61	30.20
Platelet count (M: [13.1-26.2] × 10⁴/μL and W: [13-36.9] × 10⁴/μL)	n	96	29	0.82183	0.997/0.938-1.059
	Median	18.75	16.80
	Q1 (25%)	15.35	15.50
	Q3 (75%)	21.90	24.03
AST	n	96	29	< 0.00001	1.057/1.033-1.082
	Median	30.0	66.0
	Q1 (25%)	23.0	52.5
	Q3 (75%)	42.5	105.5
ALT	n	96	29	< 0.00001	1.04/1.023-1.058
	Median	29.5	80.0
	Q1 (25%)	20.0	51.3
	Q3 (75%)	51.0	123.5
AST/ALT	n	96	29	0.04739	0.543/0.212-1.391
	Median	1.086	0.837
	Q1 (25%)	0.798	0.651
	Q3 (75%)	1.370	1.165
Alkaline phosphatase (38-113 U/L)	n	96	29	0.81045	1.003/0.99-1.016
	Median	81.5	85.0
	Q1 (25%)	65.5	63.3
	Q3 (75%)	103.5	104.3
γ-glutamyl transpeptidase (M: < 70 U/L and W: < 30 U/L)	n	96	29	0.00269	1.003/1-1.005
	Median	50.5	89.0
	Q1 (25%)	27.0	55.8
	Q3 (75%)	108.0	162.3
Ferritin (M: 39.4-340 ng/mL and W: 3.6-114 ng/mL)	n	85	25	0.00004	1.003/1.001-1.005
	Median	171.2	398.5
	Q1 (25%)	106.9	248.8
	Q3 (75%)	300.3	701.3
IgG (870-1700 mg/dL)	n	76	24	0.42663	1/0.999-1.002
	Median	1285.5	1327.5
	Q1 (25%)	1125.0	1132.0
	Q3 (75%)	1433.5	1582.0
IgM (M: 33-190 mg/dL and W: 46-260 mg/dL)	n	66	22	0.54697	1.003/0.996-1.01
	Median	86.5	90.5
	Q1 (25%)	56.0	58.0
	Q3 (75%)	123.0	134.0
IgA (110-410 mg/dL)	n	69	19	0.18399	1.002/0.999-1.005
	Median	251.0	322.0
	Q1 (25%)	195.5	201.0
	Q3 (75%)	315.8	430.3
Ammonia (30-80 μg/dL)	n	94	29	0.06502	0.976/0.948-1.005
	Median	40.0	37.0
	Q1 (25%)	35.0	29.8
	Q3 (75%)	51.0	43.0
TG (50-149 mg/dL)	n	96	29	0.00117	1.004/1-1.008
	Median	100.5	160.0
	Q1 (25%)	70.5	114.8
	Q3 (75%)	165.5	234.3
LDL (70-139 mg/dL)	n	93	28	0.64258	1.003/0.991-1.015
	Median	109.0	113.0
	Q1 (25%)	91.3	92.0
	Q3 (75%)	139.0	141.0
HDL (M: 40-80 mg/dL and W: 40-90 mg/dL)	n	96	29	0.00340	0.954/0.924-0.985
	Median	63.0	54.0
	Q1 (25%)	52.0	42.8
	Q3 (75%)	74.5	61.8
TG/HDL	n	96	29	0.00041	1.281/1.064-1.544
	Median	1.654	3.260
	Q1 (25%)	1.109	1.764
	Q3 (75%)	3.014	5.545
Small dense LDL (> 35 mg/dL)	n	71	23	0.15677	1.01/0.99-1.031
	Median	35.4	39.6
	Q1 (25%)	20.9	29.8
	Q3 (75%)	48.5	52.0
Hemoglobin A1c (4.8%-6%)	n	93	28	0.02446	1.274/0.883-1.839
	Median	5.8	6.1
	Q1 (25%)	5.5	5.8
	Q3 (75%)	6.2	6.6

The odds ratio and 95% confidence interval were calculated using univariate logistic analysis. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; HDL: High-density lipoprotein; Ig: Immunoglobulin; LDL: Low-density lipoprotein; M: Men; PT: Prothrombin time; Q1: Quartile 1 (25%); Q3: Quartile 3 (75%); TG: Triglyceride; W: Women.

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Citation: Ichikawa T, Miuma S, Yamashima M, Yamamichi S, Koike M, Nakano Y, Yajima H, Miyazaki O, Ikeda T, Okamura T, Komatsu N, Yoshino M, Miyaaki H. Cytokeratin 18 fragment is associated with steatosis-associated fibrosis estimator score and lipid in patients with steatotic liver disease. World J Hepatol 2025; 17(11): 110698
URL: https://www.wjgnet.com/1948-5182/full/v17/i11/110698.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i11.110698

Ichikawa T, Miuma S, Yamashima M, Yamamichi S, Koike M, Nakano Y, Yajima H, Miyazaki O, Ikeda T, Okamura T, Komatsu N, Yoshino M, Miyaaki H. Cytokeratin 18 fragment is associated with steatosis-associated fibrosis estimator score and lipid in patients with steatotic liver disease. World J Hepatol 2025; 17(11): 110698 [PMID: 41368122 DOI: 10.4254/wjh.v17.i11.110698]

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