Direct-acting antiviral therapy reduces variceal rebleeding and improves liver function in hepatitis C virus-related cirrhosis: A multicenter retrospective cohort study

doi:10.4254/wjh.v17.i11.110638

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Hepatol. Nov 27, 2025; 17(11): 110638
Published online Nov 27, 2025. doi: 10.4254/wjh.v17.i11.110638

Table 7 Competing risk analysis (Fine and Gray Model)

Variable	Sub-distribution HR (95%CI)	P value
DAA treatment	0.44 (0.26-0.74)	0.002^a
MELD score (> 10)	1.89 (1.23-2.91)	0.004^a
Child-Pugh B	1.56 (1.02-2.38)	0.039^a
Age (> 50 years)	1.45 (1.02-2.06)	0.038^a
Deceased during follow-up	2.10 (1.30-3.40)	0.003^a

^aP < 0.05.

Subdistribution HR: Hazard ratio accounting for competing risks (e.g., death, liver transplantation). MELD: Model for end-stage liver disease; DAA: Direct-acting antiviral.

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Citation: Abdel Hafez RS, Semeya AA, Elgamal R, Othman AA. Direct-acting antiviral therapy reduces variceal rebleeding and improves liver function in hepatitis C virus-related cirrhosis: A multicenter retrospective cohort study. World J Hepatol 2025; 17(11): 110638
URL: https://www.wjgnet.com/1948-5182/full/v17/i11/110638.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i11.110638

Abdel Hafez RS, Semeya AA, Elgamal R, Othman AA. Direct-acting antiviral therapy reduces variceal rebleeding and improves liver function in hepatitis C virus-related cirrhosis: A multicenter retrospective cohort study. World J Hepatol 2025; 17(11): 110638 [PMID: 41368107 DOI: 10.4254/wjh.v17.i11.110638]

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