Direct-acting antiviral therapy reduces variceal rebleeding and improves liver function in hepatitis C virus-related cirrhosis: A multicenter retrospective cohort study

Table 5 Time-dependent Cox regression for model for end-stage liver disease score progression

Variable	HR (95%CI)	P value
DAA treatment	0.42 (0.25-0.71)	0.001
MELD score (Time-dependent)	1.89 (1.23-2.91)	0.004
Child-Pugh Class B	1.56 (1.02-2.38)	0.039
Platelets < 150 × 10³/μL	1.78 (1.15-2.76)	0.010

Time-dependent Cox regression analysis was performed to account for changes in model for end-stage liver disease (MELD) score over time. MELD scores were updated at each follow-up visit. MELD: Model for end-stage liver disease; DAA: Direct-acting antiviral.