Direct-acting antiviral therapy reduces variceal rebleeding and improves liver function in hepatitis C virus-related cirrhosis: A multicenter retrospective cohort study

Table 4 Multivariable Cox regression and Time-dependent covariate analysis

Multivariable Cox regression analysis			Time-dependent covariate analysis
Variable	Adjusted HR (95%CI)	P value	Variable	HR (95%CI)	P value
DAA treatment (Group A)	0.42 (0.25-0.71)	0.001a	MELD score change	1.89 (1.23-2.91)	0.004a
MELD score (> 10)	1.89 (1.23-2.91)	0.004a	Child-Pugh change	1.56 (1.02-2.38)	0.039a
Child-Pugh class B	1.56 (1.02-2.38)	0.039a
Age (> 50 years)	1.45 (1.02-2.06)	0.038a
Platelets (< 150 × 10³/μL)	1.78 (1.15-2.76)	0.010a

^aP < 0.05.

MELD: Model for end-stage liver disease; DAA: Direct-acting antiviral.