Liver as a metabolic sensor in gestational diabetes: Implications for offspring’s liver and diabetes risk

doi:10.4254/wjh.v17.i11.110185

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Nov 27, 2025; 17(11): 110185
Published online Nov 27, 2025. doi: 10.4254/wjh.v17.i11.110185

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Figure 1 Maternal hepatic adaptations in healthy pregnancy vs disruptions in gestational diabetes mellitus. ↑: Increased; ↓: Decreased; FXR: Farnesoid X receptor (a nuclear receptor regulating bile acid and lipid metabolism); VLDL: Very low-density lipoprotein; FGF21: Fibroblast growth factor 21; ANGPTL8: Angiopoietin-like protein 5; Hepatokines: Liver-secreted hormones that influence systemic metabolic homeostasis; Redox: Reduction-oxidation (balance between pro-oxidant and antioxidant processes in cells).

Citation: Abdalla MMI, Ismail-Khan M. Liver as a metabolic sensor in gestational diabetes: Implications for offspring’s liver and diabetes risk. World J Hepatol 2025; 17(11): 110185
URL: https://www.wjgnet.com/1948-5182/full/v17/i11/110185.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i11.110185

Abdalla MMI, Ismail-Khan M. Liver as a metabolic sensor in gestational diabetes: Implications for offspring’s liver and diabetes risk. World J Hepatol 2025; 17(11): 110185 [PMID: 41368113 DOI: 10.4254/wjh.v17.i11.110185]

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