Sex-related differences in treatment outcomes of chronic hepatitis C with direct-acting antivirals

doi:10.4254/wjh.v17.i10.110430

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Oct 27, 2025; 17(10): 110430
Published online Oct 27, 2025. doi: 10.4254/wjh.v17.i10.110430

Table 2 Sex-based comorbidity differences across age groups, n (%)

Comorbidities	15-44 years		45-55 years		> 55 years
Comorbidities	Women (n = 3118)	Men (n = 4163)	Women (n = 1689)	Men (n = 2185)	Women (n = 4650)	Men (n = 3181)
Any comorbidity	1172 (37.6)	1748 (41.99)	1012 (59.92)	1284 (58.76)	3767 (81.01)	2596 (81.61)
Autoimmune diseases	88 (2.82)	30 (0.72)	58 (3.43)	19 (0.87)	163 (3.5)	28 (0.88)
DM	75 (2.41)	167 (4.01)	131 (7.76)	250 (11.44)	814 (17.5)	772 (24.27)
Hypertension	197 (6.32)	458 (11)	429 (25.4)	589 (26.96)	2591 (55.72)	1711 (53.79)
Renal disease	64 (2.1)	96 (2.31)	71 (4.2)	73 (3.34)	183 (3.94)	204 (6.41)
Depression	106 (3.4)	126 (3.03)	106 (6.28)	76 (3.48)	230 (4.95)	101 (3.18)
Psychiatric disorders¹	21 (0.67)	83 (1.99)	17 (1.01)	47 (2.15)	50 (1.08)	44 (1.38)
Non-HCC tumors	19 (0.61)	29 (0.7)	43 (2.55)	23 (1.1)	153 (3.29)	141 (4.43)
History of HCC	3 (0.10)	18 (0.43)	6 (0.36)	44 (2.01)	83 (1.78)	144 (4.53)
HBV coinfection	333 (10.68)	532 (12.78)	251 (14.86)	413 (18.9)	625 (13.44)	501 (15.75)
HIV coinfection	161 (5.16)	530 (12.73)	95 (5.62)	282 (12.91)	16 (0.34)	52 (1.63)

¹Schizophrenia, bipolar affective disorder, psychotic disorders, dissociative disorders, personality disorders.

Psychiatric disorders category includes conditions such as anxiety, bipolar disorder, schizophrenia, etc. DM: Diabetes mellitus; HCC: Hepatocellular carcinoma; HIV: Human immunodeficiency virus; HBV: Hepatitis B virus.

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Citation: Feyissa GD. Sex-related differences in treatment outcomes of chronic hepatitis C with direct-acting antivirals. World J Hepatol 2025; 17(10): 110430
URL: https://www.wjgnet.com/1948-5182/full/v17/i10/110430.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i10.110430

Feyissa GD. Sex-related differences in treatment outcomes of chronic hepatitis C with direct-acting antivirals. World J Hepatol 2025; 17(10): 110430 [PMID: 41179721 DOI: 10.4254/wjh.v17.i10.110430]

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