Metabolic and hepatic effects of semaglutide and empagliflozin on metabolic dysfunction-associated steatotic liver disease mice

Figure 2 Changes in serological indicators. A: Total cholesterol. ^aP < 0.01 indicates high-fat group (HFD group) vs control group (NCD group), ^bP < 0.01 indicates HFD vs Sema, ^cP < 0.01 indicates NCD vs Sema, ^dP < 0.01 indicates HFD vs Empa, ^eP < 0.01 indicates NCD vs Empa; B: Low-density lipoprotein cholesterol. ^aP < 0.01 indicates HFD vs NCD, ^bP < 0.01 indicates HFD vs Sema, ^cP < 0.01 indicates HFD vs Empa; C: High-density lipoprotein cholesterol. ^aP < 0.01 indicates HFD vs NCD, ^bP < 0.01 indicates HFD vs Sema, ^cP < 0.01 indicates HFD vs Empa; D: Triglycerides. ^aP < 0.01 indicates HFD vs NCD, ^bP < 0.01 indicates Sema vs Empa, ^cP < 0.01 indicates NCD vs Empa; E: Malondialdehyde. ^aP < 0.01 indicates HFD vs NCD, ^bP < 0.01 indicates HFD vs Sema, ^cP < 0.01 indicates HFD vs Empa; F: Superoxide dismutase. ^aP < 0.01 indicates HFD vs NCD, ^bP < 0.01 indicates HFD vs Sema, ^cP < 0.01 indicates NCD vs Sema, ^dP < 0.01 indicates HFD vs Empa, ^eP < 0.01 indicates NCD vs Empa; G: Tumour necrosis factor-α. ^aP < 0.01 indicates HFD vs NCD, ^bP < 0.01 indicates HFD vs Sema, ^cP < 0.01 indicates NCD vs Sema, ^dP < 0.01 HFD vs Empa, ^eP < 0.01 indicates NCD vs Empa; H: Interleukin (IL)-6; ^aP < 0.01 indicates HFD vs NCD, ^bP < 0.01 indicates HFD vs Sema, ^cP < 0.01 indicates HFD vs Empa; I: IL-1β. ^aP < 0.01 indicates HFD vs NCD, ^bP < 0.01 indicates HFD vs Sema, ^cP < 0.01 indicates HFD vs Empa, ^dP < 0.01 indicates NCD vs Empa; J: Alanine aminotransferase. ^aP < 0.01 indicates HFD vs NCD, ^bP < 0.01 indicates HFD vs Sema, ^cP < 0.01 HFD vs Empa; K: Aspartate aminotransferase. ^aP < 0.01 indicates HFD vs NCD, ^bP < 0.01 indicates HFD vs Sema, ^cP < 0.01 indicates HFD vs Empa; L: Uric acid. ^aP < 0.01 indicates HFD vs NCD, ^bP < 0.01 indicates HFD vs Sema, ^cP < 0.01 indicates NCD vs Empa; n = 4/group. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; HDL-C: High-density lipoprotein cholesterol; HFD: A high-fat group; IL: Interleukin; LDL-C: Low-density lipoprotein cholesterol; MDA: Malondialdehyde; NCD: A control group; SOD: Superoxide dismutase; TC: Total cholesterol; TG: Triglycerides; TNF-α: Tumour necrosis factor-α; UA: Uric acid.