Clinicopathological insights and management of liver metastases: Current advances and future perspectives

Figure 3 Integrated multidisciplinary strategy for managing liver metastases. The process initiates with a comprehensive evaluation by a multidisciplinary team, leading to the application of structured clinical algorithms. Based on this assessment, patients are stratified into three clinical categories: (1) Those with respectable disease who may undergo primary or staged liver resection; (2) Borderline or potentially convertible cases, where tumor reduction strategies and ongoing evaluation are implemented; and (3) Patients with unrespectable disease, who are considered for systemic treatments, locoregional interventions, or palliative care. Prognostic assessment tools and risk stratification frameworks are employed throughout to support individualized treatment decisions and predict clinical outcomes. MDT: Multidisciplinary team.