Quality of life in hereditary haemochromatosis: Scoping review of symptoms and initial ranking of symptoms by a special interest group

Table 2 Frequency of symptoms reported in eligible studies

Symptom	Referenced articles	Frequency of references
Joint pain or stiffness	37	762
Abdominal pain	26	416
Fatigue, chronic fatigue, tiredness	24	314
Problems related to insurance or unemployment	11	111
Reduced psychological wellbeing (depression or low mood)	14	97
Sexual problems (decreased libido or impotence)	21	91
Skin darkening or pigmentation	18	74
Cognitive issues (confusion, memory loss, brain fog)	8	55
Early menopause/issues with menstruation, missing periods or irregular periods/fertility issues	4	25
Hair loss	3	23
Unexplained weight loss	7	22
Reduced physical functioning/ability to do daily tasks	8	20
Heart fluttering or arrhythmia	4	19
Issues with social functioning	6	18
Reduced vitality	6	17
Weakness	6	13
Itchiness	2	10
Breathing problems	3	7
Unexplained weight gain	1	1