Alpha-1 antitrypsin deficiency and Pi*Z allele as important co-factors in the development of liver fibrosis

Table 1 Baseline characteristics of the study population

Variable	Study population’s characteristics
Sex, n (%)
Female	28 (40.6)
Male	41 (59.4)
Age at diagnosis (yr), mean ± SD	45 ± 17
Age (yr), mean ± SD	50 ± 17
BMI (kg/m2), mean ± SD	26.4 ± 4.5
Waist circumference (cm), mean ± SD	94 ± 13
Arterial hypertension, n (%)	24 (34.8)
Type 2 DM, n (%)	14 (20.3)
Dyslipidaemia, n (%)	27 (39.1)
Obesity, n (%)	15 (21.7)
Metabolic syndrome, n (%)	22 (31.9)
Regular alcohol intake, n (%)	29 (42.0)
Smoking habits, n (%)
Non-smoker	46 (66.7)
Smoker	7 (10.1)
Ex-smoker	16 (23.2)
AAT clinical presentation, n (%)
Respiratory	40 (58.0)
Hepatic	17 (24.6)
Screening	12 (17.4)
AAT value at diagnosis (mg/dL), median	67
AAT phenotype, n (%)
MZ	34 (49.3)
SZ	14 (20.3)
ZZ	7 (10.1)
SS	6 (8.7)
MS	4 (5.8)
MMHeerlen	2 (2.9)
SMHeerlen	2 (2.9)
FEV1 (%), mean ± SD	94 ± 29
DLCO, mL of CO/s/mmHg, median	92

BMI: Body mass index; DM: Diabetes mellitus; AAT: Alpha-1 antitrypsin; FEV1: Forced expiratory volume in the first second; DLCO: Diffusing capacity of the lungs for carbon monoxide.