Lean body mass index is a marker of advanced tumor features in patients with hepatocellular carcinoma

Table 3 Multivariable cox regression model of cirrhotic patient and tumor risk factors associated with survival after hepatocellular carcinoma diagnosis

Characteristic	Adjusted HR (95%CI)	P value
Age	1.0 (0.99-1.01)	0.58
Female (Ref.: Male)	0.94 (0.76-1.16)	0.57
Race (Ref.: White)		0.72
Asian	0.98 (0.55-1.76)
Black	0.87 (0.70-1.08)
Hispanic	0.94 (0.57-1.55)
Other	0.81 (0.45-1.45)
BMI classification (kg/m²) (Ref.: BMI < 25)		0.36
BMI 25.0-29.9	0.87 (0.72-1.06)
BMI ≥ 30	0.90 (0.73-1.11)
Diabetes	0.96 (0.81-1.14)	0.64
Alcohol abuse	1.10 (0.90-1.34)	0.35
HCV SVR	0.27 (0.21-0.35)	< 0.0001
Tumor size (cm)	1.08 (1.05-1.12)	< 0.0001
AFP (ng/mL) (Ref.: < 20)		< 0.0001
20-200	1.51 (1.23-1.85)
> 200	1.93 (1.61-2.32)
Tumor within Milan criteria	0.59 (0.48-0.72)	< 0.0001
Liver transplantation	0.10 (0.06-0.16)	< 0.0001
Any method of screening within 2 years before HCC diagnosis (Ref.: No)		0.0634
Yes	1.01 (0.85-1.21)
Unknown	0.79 (0.63-0.99)

BMI: Body mass index; AFP: Alpha fetoprotein; HCC: Hepatocellular carcinoma; HR: Hazard ratios; HCV: Hepatitis C virus; SVR: Sustained virologic response.