Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus

Table 4 Genotype and allele frequencies of the single-nucleotide polymorphisms in the metabolic-associated fatty liver disease compared with Chinese Dai

Gene	SNP	B allele	Dominate model		Recessive model
			OR (95%CI)	P value	OR (95%CI)	P value
PNPLA3	rs738409	G	1.970 (1.160-3.345)	0.012a	1.074 (0.377-3.061)	0.894
APOC3	rs2854116	C	6.109 (2.490-14.986)	< 0.001a	0.485 (0.259-0.907)	0.022b
LEP	rs7799039	G	0.840 (0.300-2.355)	0.740	0.790 (0.469-1.332)	0.376
GHRL	rs27647	G	0.953 (0.491-1.850)	0.888	1.646 (1.486-1.823)	1.000
LIPC	rs1800588	T	0.889 (0.525-1.504)	0.661	1.042 (0.494-2.199)	0.914
APOB	rs10495712	A	1.799 (0.762-4.251)	0.176	1.642 (1.486-1.823)	1.000
APOA5	rs662799	G	0.854 (0.507-1.438)	0.552	0.960 (0.330-2.790)	0.940

^aP value < 0.05 compared between metabolic-associated fatty liver disease (MAFLD) vs Chinese Dai in dominant model.

^bP value < 0.05 compared between MAFLD vs Chinese Dai in recessive model, B-allele expressed risk allele. Data expressed as n (%). MAFLD: Metabolic-associated fatty liver disease; PLWH: People living with human immunodeficiency virus; SNP: Single-nucleotide polymorphism; OR: Odds ratio.