Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus

doi:10.4254/wjh.v16.i3.366

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World Journal of Hepatology

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World J Hepatol. Mar 27, 2024; 16(3): 366-378
Published online Mar 27, 2024. doi: 10.4254/wjh.v16.i3.366

Table 3 Genotype and allele frequencies of the single-nucleotide polymorphisms in the people living with human immunodeficiency virus and metabolic-associated fatty liver disease compared with people living with human immunodeficiency virus and non-metabolic-associated fatty liver disease group

Gene	SNP	B allele	Dominant model				Recessive model
			PLWH and MAFLD vs PLWH and non-MAFLD		PLWH and MAFLD vs Chinese Dai		PLWH and MAFLD vs PLWH and non-MAFLD		PLWH and MAFLD vs Chinese Dai
			OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
PNPLA3	rs738409	G	1.476 (0.809-2.694)	0.204	2.539 (1.382-4.665)	0.002^b	0.94 (0.276-3.202)	0.921	0.929 (0.273-3.166)	0.907
APOC3	rs2854116	C	1.117 (0.543-2.297)	0.764	1.203 (0.588-2.462)	0.613	0.798 (0.411-1.550)	0.506	0.828 (0.425-1.614)	0.579
LEP	rs7799039	G	0.704 (0.287-1.727)	0.422	0.408 (0.146-1.142)	0.080	0.886 (0.491-1.601)	0.689	0.730 (0.403-1.322)	0.298
GHRL	rs27647	G	0.466 (0.217-1.001)	0.047^a	0.704 (0.317-1.566)	0.388	2.146 (1.832-2.514)	0.469	2.134 (1.823-2.499)	0.472
LIPC	rs1800588	T	1.506 (0.806-2.815)	0.198	1.676 (0.898-3.128)	0.104	1.053 0.452-2.456)	0.905	1.040 (0.446-2.427)	0.928
APOB	rs10495712	A	1.264 (0.557-2.871)	0.575	2.156 (0.855-5.436)	0.098	1.134 (0.070-18.422)	1.000	2.134 (1.823-2.499)	0.472
APOA5	rs662799	G	0.914 (0.505-1.654)	0.766	0.960 (0.330-2.790)	0.940	0.629 (0.177-2.231)	0.470	0.734 (0.200-2.697)	0.751

Data expressed as OR odds ratio, CI confidence interval.

^aP value < 0.05 compared between people living with human immunodeficiency virus (PLWH) and metabolic-associated fatty liver disease (MAFLD) vs PLWH and non-MAFLD.

^bP value < 0.05 compared between PLWH and MAFLD vs Chinese Dai was represented as general population, B-allele expressed risk allele. MAFLD: Metabolic-associated fatty liver disease; PLWH: People living with human immunodeficiency virus; SNP: Single-nucleotide polymorphism.

Citation: Choochuay K, Kunhapan P, Puangpetch A, Tongsima S, Srisawasdi P, Sobhonslidsuk A, Sungkanuparph S, Biswas M, Sukasem C. Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus. World J Hepatol 2024; 16(3): 366-378
URL: https://www.wjgnet.com/1948-5182/full/v16/i3/366.htm
DOI: https://dx.doi.org/10.4254/wjh.v16.i3.366