Gut microbiome and metabolic-associated fatty liver disease: Current status and potential applications

doi:10.4254/wjh.v15.i7.867

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 15, Issue 7

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (3043)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-3) series, Tables (1-1) series.

Item

Count

PDF

WORD

HTML

1643

Figures (1-3)

137

Tables (1-1)

132

Sum=2008

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

172

Download

372

Sum=544

Publishing Process of This Article

Item

Count

Browse

100

Download

242

Sum=342

Jul 27, 2023 (publication date) through May 20, 2024

Times Cited of This Article

Times Cited (1)

Journal Information of This Article

Publication Name

World Journal of Hepatology

ISSN

1948-5182

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Hepatol. Jul 27, 2023; 15(7): 867-882
Published online Jul 27, 2023. doi: 10.4254/wjh.v15.i7.867

Table 1 Studies presenting gut dysbiosis in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis

			Alterations of GM (↑/↓)
Country	Subjects	Year	Phylum	Family	Genus/Species	Ref.
United States	Obese patients without NASH (n = 25), NASH (n = 22), Controls (n = 16)	2013	↑Bacteroidetes; ↑Proteobacteria; ↓Firmicutes; ↓Actinobacteria	↓Bifidobacteriaceae; ↑Alcaligenaceae; ↓Clostridiales family XI; ↑Campylobacteraceae; ↓Lachnospiraceae; ↑Enterobacteriaceae	↑Prevotella; ↑Escherichia	[69]
Canada	NAFLD (n = 33) vs Controls (n = 17)	2013	↓Bacteroidetes	/	↑Clostridium coccoides	[124]
Canada	NAFLD (n = 30) vs Controls (n = 30)	2013	↑Proteobacteria; ↑Firmicutes; ↓Bacteroidetes	↑Kiloniellaceae; ↑Pasteurellaceae; ↑Lactobacillaceae; ↑Lachnospiraceae; ↑Veillonellaceae; ↓Ruminococcaceae; ↓Porphyromonadaceae	↑Lactobacillu; ↑Robinsoniella; ↑Roseburia; ↑Dorea; ↓Oscillibacter	[125]
Hong Kong	NASH (n = 16) vs Controls (n = 22)	2013	↓Firmicutes	/	↓Faecalibacterium; ↓Anaerosporobacter; ↑Parabacteroides; ↑Allisonella	[126]
China	NAFLD (n = 53) vs Controls (n = 32)	2015	↑Firmicutes; ↑Proteobacteria	↑Peptostreptococcaceae; ↑Lactobacillaceae; ↓Ruminococcaceae; ↓Porphyromonadaceae	↑Escherichia; ↑Lactobacillus; ↑Streptococcus; ↑Anaerobacter; ↓Prevotella	[127]
United States	Controls (n = 26), obese (n = 11), NAFLD (n = 13)	2015	↑Actinobacteria	/	↓Erysipelotrichia; ↑Prevotella; ↓Alphaproteobacteria; ↑Clostridia; ↓Verrucomicrobia; ↑Fusobacteria; ↑Epsilonproteobacteria; ↑Gammaproteobacteria	[67]
France	NASH (n = 35) vs Controls (n = 22)	2016	↑Proteobacteria	↑Enterobacteriaceae; ↓Ruminococcaceae	↑Ruminococcus; ↓Prevotella; ↑Escherichia; ↓Anaerospacter; ↓Coprococcus; ↓Eubacterium; ↓Faecalibacterium; ↑Bacteroides	[128]
Italy	NAFLD (n = 61) vs Controls (n = 54)	2017	↑Actinobacteria; ↓Bacteroidetes	↓Rikenellaceae	↑Bradyrhizobium; ↑Anaerococcus; ↑Peptoniphilus; ↑Ruminococcus; ↓Oscillopira; ↑Dorea; ↑Blautia; ↑Propionibacterium acnes	[129]
China	NAFLD (n = 43) vs Controls (n = 83)	2016	↑Bacteroidetes; ↓Firmicutes	↑Bacteroidaceae; ↓Lachnospiraceae; ↑Prevotellaceae; ↓Ruminococcaceae; ↓Lactobacillaceae; ↓Peptostreptococcaceae	↓Coprococcus; ↓Anaerosporobacter; ↓Anaerotruncus; ↓Ruminococcus; ↓Lactobacillus	[130]
China	NAFLD (n = 25) vs Controls (n = 22)	2017	↑Proteobacteria; ↓Bacteroidetes	↑Lachnospiraceae; ↑Enterobacteriaceae; ↓Prevotellaceae; ↓Ruminococcaceae; ↑Erysipelotrichaceae; ↑Streptococcaceae	↑Fusobacteria; ↓Prevotella; ↑Blautia; ↑Escherichia; ↑Shigella; ↑Fusobacteria; ↑Escherichia Shigella	[131]
Canada	NAFLD (n = 39) vs Controls (n = 28)	2018	↓Firmicutes; ↓Bacteroidetes	↑Lactobacillaceae	↓Ruminococcus; ↓Faecalibacterium; ↓Coprococcus	[132]
Italy	Obese, NAFL and NASH (n = 61) and Controls (n = 54)	2016	/	/	↑Lactobacilli; ↓Bifidobacteria; ↑Lactobacilli mucosae; ↓Bifidobacteria longum; ↓Bifidobacteria adolescent; ↓Bifidobacteria bifidum	[133]
Brazil	NASH (n = 13) vs Controls (n = 10)	2017	/	/	↑Bacteroides; ↑Lactobacilli; ↓Ruminococcu; ↓Bifidobacterium; ↑Prevotella; ↓Faecalibacterium	[134]
China	NAFLD (n = 30) vs Controls (n = 37)	2018	/	↑Lactobacillaceae; ↑Veillonellaceae; ↑Peptostreptococcaceae; ↑Coprobacillaceae; ↑Erysipelotrichaceae; ↓Paraprevotellaceae; ↓Victivallaceae	↑Porphyromonas; ↑Clostridium; ↑Blautia; ↑Dorea; ↑Peptococcus; ↑Peptococcaceae_rc4-4; ↑Mitsuokella; ↑Slackia; ↑Succinivibrio; ↓Odoribacter; ↓Coprococcus; ↓Proteus	[135]
Germany	NAFLD (n = 90) vs Controls (n = 21)	2020	↓Bacteroidetes	↓Ruminococcaceae; ↑Lactobacillaceae; ↑Veillonellaceae	↑Dorea	[136]
United States	NAFLD (n = 44) vs Controls (n = 29)	2020	↓Bacteroidetes	/	↓Prevotella; ↓Gemmiger; ↓Oscillospira	[137]

NAFLD: Non-alcoholic fatty liver disease; NASH: Non-alcoholic steatohepatitis.

Citation: Guo GJ, Yao F, Lu WP, Xu HM. Gut microbiome and metabolic-associated fatty liver disease: Current status and potential applications. World J Hepatol 2023; 15(7): 867-882
URL: https://www.wjgnet.com/1948-5182/full/v15/i7/867.htm
DOI: https://dx.doi.org/10.4254/wjh.v15.i7.867