Noninvasive biomarkers in pediatric nonalcoholic fatty liver disease

doi:10.4254/wjh.v15.i5.609

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May 27, 2023 (publication date) through Apr 25, 2024

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World Journal of Hepatology

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1948-5182

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World J Hepatol. May 27, 2023; 15(5): 609-640
Published online May 27, 2023. doi: 10.4254/wjh.v15.i5.609

Table 1 Cellular location(s) of synthesis of circulating biomarkers in nonalcoholic fatty liver disease

Serological biomarker	Cellular location(s) of synthesis
Adiponectin	Adipocytes
Adipo R2	Hepatocytes, skeletal muscle
ALT	Hepatocytes
Ang-2	Liver sinusoidal endothelial cells
CatD	Lysosomes
Chemerin	Adipocytes
CK18	Hepatocytes
FGF21	Hepatocytes
HA	Hepatic stellate cells
IL-1β	Adipocytes
IL-6	Adipocytes
IL-17	T helper 17 cells
IL-18	Macrophages
Leptin	Adipocytes
PIIINP	Released during procollagen processing
PRO-C3	Extracellular matrix
RBP4	Adipocytes, Hepatocytes
Resistin	Adipocytes
Visfatin	Adipocytes, Hepatocytes

IL: Interleukin; Adipo R2: Soluble adiponectin receptor 2; FGF: Fibroblast growth factor; RBP4: Retinol binding protein 4; ALT: Alanine aminotransferase; Ang-2: Angiopoietin-2; CK18: Cytokeratin 18; CatD: Cathepsin D; HA: Hyaluronic acid; PRO-C3: N-terminal type III collagen propeptide; PIIINP: Amino-terminal propeptide of type III procollagen. Serological biomarkers are listed in the order they appear in the text.

Citation: Jayasekera D, Hartmann P. Noninvasive biomarkers in pediatric nonalcoholic fatty liver disease. World J Hepatol 2023; 15(5): 609-640
URL: https://www.wjgnet.com/1948-5182/full/v15/i5/609.htm
DOI: https://dx.doi.org/10.4254/wjh.v15.i5.609