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World Journal of Hepatology
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1948-5182
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©The Author(s) 2023.
World J Hepatol. May 27, 2023; 15(5): 609-640
Published online May 27, 2023. doi: 10.4254/wjh.v15.i5.609
Table 1 Cellular location(s) of synthesis of circulating biomarkers in nonalcoholic fatty liver disease
Serological biomarker
Cellular location(s) of synthesis
AdiponectinAdipocytes
Adipo R2Hepatocytes, skeletal muscle
ALTHepatocytes
Ang-2Liver sinusoidal endothelial cells
CatDLysosomes
ChemerinAdipocytes
CK18Hepatocytes
FGF21Hepatocytes
HAHepatic stellate cells
IL-1βAdipocytes
IL-6Adipocytes
IL-17T helper 17 cells
IL-18Macrophages
LeptinAdipocytes
PIIINPReleased during procollagen processing
PRO-C3Extracellular matrix
RBP4Adipocytes, Hepatocytes
ResistinAdipocytes
VisfatinAdipocytes, Hepatocytes
IL: Interleukin; Adipo R2: Soluble adiponectin receptor 2; FGF: Fibroblast growth factor; RBP4: Retinol binding protein 4; ALT: Alanine aminotransferase; Ang-2: Angiopoietin-2; CK18: Cytokeratin 18; CatD: Cathepsin D; HA: Hyaluronic acid; PRO-C3: N-terminal type III collagen propeptide; PIIINP: Amino-terminal propeptide of type III procollagen. Serological biomarkers are listed in the order they appear in the text.
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