mRNA transcriptome profiling of human hepatocellular carcinoma cells HepG2 treated with Catharanthus roseus-silver nanoparticles

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World Journal of Hepatology

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1948-5182

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Basic Study

World J Hepatol. Mar 27, 2023; 15(3): 393-409
Published online Mar 27, 2023. doi: 10.4254/wjh.v15.i3.393

Table 3 Pathway functional enrichment results

Pathway ID	Pathway	Genes	Hits	Adj P value
K05200	Pathway in cancer	FAS, GADD45A, BAX, PMAIP, BID, JUN, CXCL8, HMOX1, STAT1, FOS, CEBPA, VEGFA, FGF5, EGF, RHOA, FADD, FH, SMAD, MTOR, NFκBIA, CDKN1A, WNT4^a, WNT7A^a, FGFR3^a, BMP4^a, CDK4^a, CDK2^a, MDM^a	29/530	3.28E-12
K04115	p53 signaling pathway	FAS, GADD45A, SERPINE, THBS1, CDK4, BAX, CDK2, PERP, SESN1, SESN2, PMAIP1, BID, IGFBP3^a, MDM2^a	14/72	1.28E-13
K04210	Apoptosis	FAS, GADD45A, BAX, PMAIP1, BID, JUN, FOS, FADD, NFKBIA, BCL2A1, ATF4, MCL1, TNFSF10^a, RIPK1^a	14/136	9.61E-10
K04144	Endocytosis	ARF6, RHOA, EHD2, FGFR3, HSPA6, HSPA1L, VPS28, EEA1, VPS25, TSG101, STAM, SMAD, EHD4, LDLR, TFRC^a, MDM2^a	16/244	4.08E-08
K04010	MAPK signaling pathway	FAS, GADD45A, JUN, FOS, VEGFA, FGF5, CDKN1A, EGF, ATF4, HSPA6, HSPA1L, CDKN1A, HSPB1, DUSP1, NR4A1, EFNA4^a, FGFR3^a, ERBB3^a, SKP2^a	16/295	5.58E-07
K04668	TNF signalling pathway	FAS, JUN, FOS, FADD, NFKBIA, ATF4, RIPK1^a, CCL2, NOD2, CCL20^a	10/110	9.07E-07
K04350	TGF beta signaling pathway	THBS1, RHOA, SMAD2, SMAD4, BMP4, SMAD7, BAMBI, BMP6	8/90	1.66E-05
K02010	Cell cycle	GADD45A, SOX15, CDK4^a, CDK2^a, MDM2, SMAD2, SMAD4, CDKN1A, PCNA^a, MCM3^a, SKP2^a	9/124	2.09E-05
K04978	Mineral absorption	HMOX1, MT1F, MT1X, MT1H, MT1B, FTH1	6/51	3.58E-05

^aDownregulated genes.

Citation: Azhar NA, Abu Bakar SA, Citartan M, Ahmad NH. mRNA transcriptome profiling of human hepatocellular carcinoma cells HepG2 treated with Catharanthus roseus-silver nanoparticles. World J Hepatol 2023; 15(3): 393-409
URL: https://www.wjgnet.com/1948-5182/full/v15/i3/393.htm
DOI: https://dx.doi.org/10.4254/wjh.v15.i3.393

Azhar NA, Abu Bakar SA, Citartan M, Ahmad NH. mRNA transcriptome profiling of human hepatocellular carcinoma cells HepG2 treated with Catharanthus roseus-silver nanoparticles. World J Hepatol 2023; 15(3): 393-409 [PMID: 37034237 DOI: 10.4254/wjh.v15.i3.393]

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