Metabolomics in chronic hepatitis C: Decoding fibrosis grading and underlying pathways

doi:10.4254/wjh.v15.i11.1237

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Nov 27, 2023; 15(11): 1237-1249
Published online Nov 27, 2023. doi: 10.4254/wjh.v15.i11.1237

Table 1 Demographic and clinical characteristics of all study participants, distributed by fibrosis grade (Metavir score)

Variables	Healthy control	Fibrosis grade (Metavir)¹
Variables	Healthy control	F1	F2	F3	F4
Age (yr)	44 ± 12.2	50 ± 10.78	49 ± 8.6	55 ± 8.8	54 ± 11.22
Sex
Male	24 (65.0)	8 (61.5)	7 (58.3)	5 (100)	9 (60.0)
Female	26 (52.0)	5 (38.5)	5 (41.7)	0	6 (40.0)
BMI (kg/m²)	22.9 ± 2.98	28.3 ± 8.89	26.5 ± 6.26	26.9 ± 3.60	27.4 ± 7.14
HCV genotype
1²	-	10 (77.0)	8 (66.7)	3 (50.0)	12 (80.0)
Not 1³	-	3 (23.0)	4 (33.3)	3 (50.0)	3 (20.0)

¹Metavir score to assess the fibrosis grade by histopathological examination of a liver biopsy.

²HCV 1: Hepatitis C Virus genotype 1.

³HCV not 1: Hepatitis C Virus other genotypes.

BMI: Body mass index; HCV: Hepatitis C virus.

Citation: Ferrasi AC, Lima SVG, Galvani AF, Delafiori J, Dias-Audibert FL, Catharino RR, Silva GF, Praxedes RR, Santos DB, Almeida DTM, Lima EO. Metabolomics in chronic hepatitis C: Decoding fibrosis grading and underlying pathways. World J Hepatol 2023; 15(11): 1237-1249
URL: https://www.wjgnet.com/1948-5182/full/v15/i11/1237.htm
DOI: https://dx.doi.org/10.4254/wjh.v15.i11.1237