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World J Hepatol. Jan 27, 2023; 15(1): 52-67
Published online Jan 27, 2023. doi: 10.4254/wjh.v15.i1.52
Table 2 Mechanisms of autoimmunity
Item
Description
ExogenMolecular mimicry
Superantigen stimulation
Microbial and tissue damage related adjuvant effect
EndogenLoss of central and peripheral tolerance
Autoreactive B and T lymphocytes
Apoptotic defects and defects in cleaning apoptotic substance
Disturbances in cytokine balance
Change in immunoregulation