Effect of thrombocytopenia and platelet transfusion on outcomes of acute variceal bleeding in patients with chronic liver disease

Table 5 Cox-proportional analysis of variables associated with 42-days mortality in the whole cohort and after propensity score matching

	Whole cohort		After propensity score matching
Characteristics	Univariate analysis HR (95%CI)	P value	Univariate analysis HR (95%CI)	P value	Adjusted HR (95%CI)	P value
Age (yr)	1.010 (0.998-1.022)	0.118	1.016 (0.993-1.039)	0.174
Sex
Male	1		1
Female	0.682 (0.427-1.088)	0.108	0.889 (0.350-2.256)	0.804
Heart rate (per minute)	0.999 (0.990-1.007)	0.759	1.004 (0.989-1.021)	0.581
MAP (mm of Hg)	0.988 (0.976-1.000)	0.046	0.996 (0.967-1.027)	0.816
Hemoglobin (g/dL)	0.949 (0.892-1.010)	0.100	0.992 (0.872-1.128)	0.903
TLC (× 109/L)	1.047 (1.023-1.071)	< 0.001	1.034 (0.986-1.084)	0.172
Platelet count (× 109/L)	0.998 (0.995-1.000)	0.053	0.998 (0.992-1.003)	0.422
INR	1.903 (1.689-2.143)	< 0.001	1.656 (1.246-2.201)	0.001	1.361 (0.825-2.244)	0.228
Serum urea (mg/dL)	1.009 (1.006-1.012)	< 0.001	1.005 (0.998-1.012)	0.142
Creatinine (mg/dL)	1.374 (1.263-1.495)	< 0.001	1.205 (1.004-1.446)	0.046	0.985 (0.771-1.258)	0.901
Sodium (meq/L)	0.991 (0.966-1.017)	0.494	0.996 (0.943-1.052)	0.876
Bilirubin (mg/dL)	1.077 (1.061-1.094)	< 0.001	1.040 (1.010-1.072)	0.010	1.013 (0.967-1.061)	0.588
AST (IU/L)	1.001 (1.001-1.002)	< 0.001	1.001 (1.001-1.002)	< 0.001	1.001 (1.000-1.002)	0.113
ALT (IU/L)	1.002 (1.001-1.002)	< 0.001	1.001 (0.999-1.003)	0.249
Albumin (g/dL)	0.671 (0.548-0.821)	< 0.001	0.641 (0.433-0.948)	0.026	0.964 (0.619-1.501)	0.871
CTP	1.369 (1.294-1.448)	< 0.001	1.239 (1.114-1.378)	< 0.001
MELD	1.097 (1.080-1.115)	< 0.001	1.060 (1.029-1.091)	< 0.001
Ascites, yes	2.673 (1.911-3.739)	< 0.001	1.876 (0.926-3.799)	0.080	1.043 (0.431-2.525)	0.925
HCC, yes	1.637 (0.836-3.206)	0.150	1.258 (0.390-4.063)	0.701
HE, yes	5.686 (4.102-7.881)	< 0.001	3.825 (2.014-6.953)	< 0.001	2.586 (1.260-5.307)	0.010
Endotherapy, yes	0.548 (0.394-0.760)	< 0.001	0.423 (0.226-0.790)	0.007	0.589 (0.296-1.169)	0.130
Child class
A	1		1
B	1.771 (1.142-2.747)	0.011	1.002 (0.395-2.538)	0.997
C	6.785 (4.502-10.227)	< 0.001	3.759 (1.698-8.321)	0.001
Etiology
Alcohol	1		1		1
Other	0.641 (0.473-0.870)	0.004	0.600 (0.329-1.094)	0.096	0.920 (0.470-1.799)	0.808
RBC
0	1		1
1	1 0.966 (0.629-1.484)	0.874	1.158 (0.522-2.567)	0.718
≥ 2	0.741 (0.505-1.086	0.125	1.024 (0.504-2.081)	0.948
FFP transfusion	2.532 (1.762-3.637)	< 0.001	1.923 (1.040-3.555)	0.037	1.066 (0.510-2.230)	0.865
Platelet transfusion	1.489 (0.958-2.312)	0.077	1.098 (0.608-1.984)	0.757
Grade of varices (high)	1.348 (0.826-2.198)	0.232	0.880 (0.392-1.975)	0.757

AST: Aspartate transaminase; ALT: Alanine transaminase; CTP: Child-Turcotte-Pugh score; INR: Internationalized normalized ratio; EVL: Endoscopic variceal ligation; FFP: Fresh frozen plasma; HE: Hepatic encephalopathy; HCC: Hepatocellular carcinoma; MAP: Mean arterial pressure; MELD: Model for end stage liver disease; RBC: Red blood cells; TLC: Total leucocyte count.