Effect of thrombocytopenia and platelet transfusion on outcomes of acute variceal bleeding in patients with chronic liver disease

Table 4 Cox-proportional analysis of variables associated with 42-days rebleeding in the whole cohort and after propensity score matching

	Whole cohort		After propensity score matching
Characteristics	Univariate analysis HR (95%CI)	P value	Univariate analysis HR (95%CI)	P value	Model 1 (Excluding CTP)		Model 2 (Including CTP)
					Adjusted HR (95%CI)	P value	Adjusted HR (95%CI)	P value
Age (yr)	1.000 (0.987-1.013)	0.973	1.007 (0.984-1.031)	0.584
Sex
Male	1		1
Female	0.662 (0.393-1.114)	0.120	1.330 (0.560-3.158)	0.517
Heart rate (per minute)	0.995 (0.986-1.004)	0.298	1.011 (0.996-1.026)	0.157
MAP (mm of Hg)	0.979 (0.965-0.992)	0.002	0.966 (0.938-0.996)	0.024	9.972 (0.938-1.008)	0.131	0.968 (0.936-1.001)	0.057
Hemoglobin (g/dL)	0.969 (0.906-1.036)	0.349	0.914 (0.800-1.045)	0.189
TLC (× 109/L)	1.023 (0.995-1.053)	0.111	0.991 (0.933-1.052)	0.761
Platelet count (× 109/L)	0.999 (0.997-1.001)	0.360	0.995 (0.989-1.001)	0.129
INR	1.528 (1.296-1.802)	< 0.001	1.427 (0.976-2.086)	0.067	1.341 (0.784-2.295)	0.284
Serum urea (mg/dL)	1.005 (1.001-1.008)	0.012	1.004 (0.997-1.011)	0.237
Creatinine (mg/dL)	1.158 (1.021-1.314)	0.023	1.031 (0.805-1.319)	0.811
Sodium (meq/L)	0.993 (0.966-1.022)	0.647	0.980 (0.929-1.033)	0.451
Bilirubin (mg/dL)	1.065 (1.045-1.086)	< 0.001	1.016 (0.976-1.058)	0.434
AST (IU/L)	1.001 (1.000-1.001)	0.005	1.001 (1.000-1.002)	0.002	1.001 (1.000-1.002)	0.284	1.001 (1.000-1.002)	0.021
ALT (IU/L)	1.000 (0.998-1.002)	0.920	1.000 (0.998-1.003)	0.761
Albumin (g/dL)	0.833 (0.672-1.031)	0.093	0.543 (0.363-0.811)	0.003	0.690 (0.431-1.105)	0.122
CTP	1.255 (1.177-1.337)	< 0.001	1.169 (1.048-1.303)	0.005	-		1.081 (0.959-1.220)	0.203
MELD	1.057 (1.038-1.077)	< 0.001	1.028 (0.995-1.063)	0.102	-
Ascites, yes	2.525 (1.757-3.630)	< 0.001	1.906 (0.939-3.870)	0.074	0.857 (0.376-1.953)	0.713
HCC, yes	2.532 (1.367-4.690)	0.003	0.370 (0.051-2.687)	0.326
HE, yes	3.969 (2.700-5.836)	< 0.001	2.489 (1.324-4.679)	0.005	1.791 (0.836-3.836)	0.134
Endotherapy (yes)	0.702 (0.480-1.027)	0.069	0.999 (0.463-2.155)	0.998
Child class
A	1		1
B	1.849 (1.187-2.879)	0.007	1.811 (0.738-4.444)	0.195
C	4.653 (2.988-7.245)	< 0.001	3.695 (1.567-8.715)	0.003
Etiology
Alcohol	1	0.095	1	0.124
Other	0.753 (0.539-1.051)		0.622 (0.339-1.140)
RBC (units)
0	1		1		1		1
1	1.482 (0.944-2.327)	0.087	1.162 (0.464-2.910)	0.748	1.173 (0.460-2.992)	0.738	1.253 (0.493-3.180)	0.636
≥ 2	1.434 (0.979-2.098)	0.064	2.571 (1.349-4.902)	0.004	1.998 (0.962-4.152)	0.064	1.900 (0.942-3.831)	0.073
FFP transfusion	3.078 (2.096-4.518)	< 0.001	1.490 (0.777-2.858)	0.220
Platelet transfusion	2.613 (1.735-3.936)	< 0.001	2.204 (1.165-4.172)	0.015	2.924 (1.448-5.903)	0.003	2.702 (1.345-5.429)	0.005
Grade of varices (high)	0.829 (0.526-1.308)	0.421	0.671 (0.311-1.446)	0.308

AST: Aspartate transaminase; ALT: Alanine transaminase; CTP: Child-Turcotte-Pugh score; INR: Internationalized normalized ratio; EVL: Endoscopic variceal ligation; FFP: Fresh frozen plasma; HE: Hepatic encephalopathy; HCC: Hepatocellular carcinoma; MAP: Mean arterial pressure; MELD: Model for end stage liver disease; RBC: Red blood cells; TLC: Total leucocyte count.