Effect of thrombocytopenia and platelet transfusion on outcomes of acute variceal bleeding in patients with chronic liver disease

Table 3 Comparison of baseline characteristics of cirrhosis patients who received platelet and those who did not

	Before PSM analysis			After PSM analysis
Characteristics	Platelets transfusion (n = 91)	No platelets transfusion (n = 822)	P value	Platelet transfusion (n = 89)	No platelet transfusion (n = 89)	P value
Age (yr)	42 (34-50)	45 (35-54)	0.012	42 (34-50)	40 (30-50)	0.716
Sex (Male:Female)	77 (84.6): 14 (15.4)	685 (83.3): 137 (16.7)	0.882	75 (84.3): 14 (15.7)	80 (89.9): 9 (10.1)	0.372
Heart rate (per minute)	90 (84-100)	96 (86-110)	0.016	90 (85-100)	89 (82-100)	0.546
MAP (mm of Hg)	81 (75-87)	82 (74-90)	0.341	81 (75-87)	81 (73-88)	0.968
Hemoglobin (g/dL)	7.7 (6.1-9.4)	7.6 (6.1-9.4)	0.890	7.7 (6.1-9.4)	7.5 (6.3-9.0)	0.720
TLC (× 109/L)	5.6 (3.1-8.3)	6.6 (4.0-9.4)	0.012	5.6 (3.1-8.3)	7.0 (4.4-12.0)	0.002
Platelet count (× 109/L)	40.0 (32.0-58.0)	100.0 (63.0-139.0)	< 0.001	40.0 (32.0-58.0)	81 (57-126)	< 0.001
INR	1.6 (1.3-2.0)	1.5 (1.3-1.9)	0.266	1.6 (1.3-2.0)	1.7 (1.4-2.2)	0.402
Serum urea (mg/dL)	41 (28-60)	36 (24-64)	0.864	41 (28-61)	34 (24-69)	0.369
Creatinine (mg/dL)	0.7 (0.5-1.0)	0.8 (0.6-1.3)	0.003	0.7 (0.5-1.0)	0.8 (0.6-1.4)	0.040
Sodium (meq/L)	140.2 (137.0-143.0)	139.0 (135.0-142.0)	0.023	140 (137-143)	140 (135-143)	0.529
Bilirubin (mg/dL)	1.7 (0.9-3.8)	1.6 (0.9-3.0)	0.771	1.7 (0.9-3.8)	2.4 (1.3-4.8)	0.071
AST (IU/L)	49 (34-79)	51 (34-88)	0.570	49 (34-79)	67 (38-119)	0.019
ALT (IU/L)	32 (22-58)	35 (23-54)	0.905	32 (22-58)	41 (30-67)	0.029
Albumin (g/dL)	3.2 (2.7-3.8)	3.2 (2.7-3.8)	0.897	3.2 (2.7-3.8)	3.1 (2.6-3.6)	0.355
CTP	7 (6-10)	7 (6-9)	0.119	8 (6-10)	8 (6-10)	0.186
MELD	14.6 (10.9-20.2)	14.7 (11.1-20.3)	0.878	14.6 (10.9-20.2)	16.1 (12.5-24.1)	0.079
Ascites	59 (64.8)	397 (48.3)	0.003	59 (66.3)	58 (65.2)	1.000
HCC	6 (6.6)	29 (3.5)	0.150	6 (6.7)	4 (4.5)	0.747
HE	15 (16.5)	78 (9.5)	0.044	15 (16.9)	22 (24.7)	0.268
Endotherapy (yes)	71 (78.0)	640 (77.9)	1.000	72 (80.9)	71 (79.8)	1.000
Child class			0.210			0.313
A	33 (36.3)	341 (41.5)		31 (34.8)	22 (24.7)
B	34 (37.4)	327 (39.8)		34 (38.2)	37 (41.6)
C	24 (26.4)	154 (18.7)		24 (27.0)	30 (33.7)
Etiology			0.824			0.176
Alcohol	38 (41.8)	355 (43.2)		37 (41.6)	47 (52.8)
Other	53 (58.2)	467 (56.8)		52 (58.4)	42 (47.2)
RBC			0.483			0.294
0	49 (53.8)	493 (60.0)		48 (53.9)	56 (62.9)
1	15 (16.5)	128 (15.6)		14 (15.7)	15 (16.9)
≥ 2	27 (29.7)	201 (24.5)		27 (30.3)	18 (20.2)
FFP transfusion	22 (24.2)	86 (10.5)	< 0.001	22 (24.7)	22 (24.7)	1.000
Grade of varices low:high	71 (78.0)	714 (86.9)	0.026	69 (77.5)	84 (94.4)	0.002

All values are represented as n (%) or median (IQR). AST: Aspartate transaminase; ALT: Alanine transaminase; CTP: Child-Turcotte-Pugh score; INR: Internationalized normalized ratio; EVL: Endoscopic variceal ligation; FFP: Fresh frozen plasma; HE: Hepatic encephalopathy; HCC: Hepatocellular carcinoma; MAP: Mean arterial pressure; MELD: Model for end stage liver disease; RBC: Red blood cells; TLC: Total leucocyte count.