Differential distribution of gene polymorphisms associated with hypercholesterolemia, hypertriglyceridemia, and hypoalphalipoproteinemia among Native American and Mestizo Mexicans

Table 6 Association of APOB and LDLR genotypes with hypercholesterolemia in normal weight Mestizos individuals

Genotype	Non-HChol	HChol	P value	Genotype comparison	Odds ratio (95%CI)	P value
APOB -516C/T genotypes
CC	76 (58.0%)	9 (39.1%)	0.120	TT vs CC	5.33 (1.537-18.502)	0.008
CT	46 (35.1%)	8 (34.8%)	0.895	TT vs CC + CT	4.63 (1.463-14.634)	0.009
TT	9 (6.9%)	6 (26.1%)	0.005	TT vs CT	3.83 (1.069-13.746)	0.039
LDLR A1413G genotypes
AA	21 (16.5%)	1 (4.3%)	0.135	GG vs AA	3.90 (1.042-14.583)	0.043
AG	57 (44.9%)	8 (34.8%)	0.340	GG vs AA + AG	2.53 (1.216-5.282)	0.013
GG	49 (38.6%)	14 (60.9%)	0.043	GG vs AG	2.24 (1.028-4.890)	0.042

Values are expressed as number of cases and percentage. MTZ: Mestizos; HChol: Hypercholesterolemia. The Chi-square test and logistic regression test were the statistical approach.