Differential distribution of gene polymorphisms associated with hypercholesterolemia, hypertriglyceridemia, and hypoalphalipoproteinemia among Native American and Mestizo Mexicans

doi:10.4254/wjh.v14.i7.1408

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jul 27, 2022; 14(7): 1408-1420
Published online Jul 27, 2022. doi: 10.4254/wjh.v14.i7.1408

Table 5 Association of APOB -516C/T and LDLR A1413G polymorphism with lipid levels in normal weight Mestizos individuals

Variable	*APOB* -516 C/T genotypes			P value	*LDLR* A1413G genotypes			P value
Variable	CC (n = 85)	CT (n = 54)	TT (n = 15)	P value	AA (n = 22)	AG (n = 65)	GG (n = 63)	P value
TC (mg/dL)	177.8 ± 31	178.2 ± 37.4	196.2 ± 27.6	0.033^a	177.2 ± 25.7	175.4 ± 33.1	182.9 ± 34.7	0.366
TG (mg/dL)	110.4 ± 68	119.9 ± 71.3	108.7 ± 25.9	0.574	106.9 ± 47.5	98.7 ± 44.6	124.3 ± 79.8	0.094
LDL-c (mg/dL)	106.3 ± 24	107.3 ± 30.6	129.5 ± 31.6	0.017^a	103.3 ± 23.9	106.2 ± 26.8	111.8 ± 29.5	0.042^b
VLDL-c (mg/dL)	22 ± 13.6	24.3 ± 14.3	21.8 ± 5.1	0.451	21.3 ± 9.5	19.7 ± 9.0	25.1 ± 16.0	0.075
HDL-c (mg/dL)	49.3 ± 13.9	48.5 ± 10.7	50.3 ± 16.9	0.908	51.1 ± 15.3	51.6 ± 11.8	46.8 ± 13.3	0.143
Dyslipidemia, n (%)
HChol	9 (11)	8 (15)	6 (40)	0.012^a	1 (5)	8 (12)	14 (22)	0.034^b
HTG	15 (18)	14 (26)	0 (0)	0.076	3 (14)	7 (11)	15 (24)	0.315
High LDL-c	13 (15)	12 (22)	7 (47)	0.007^a	3 (14)	10 (15)	17 (27)	0.046^b
HALP	19 (22)	10 (18)	3 (20)	0.760	3 (14)	8 (12)	18 (13)	0.178

^aTT vs CC.

^bGG vs AA.

The Kruskall Wallis test and U Mann-Whitney test for quantitative variables and Chi-square test for qualitative variables were the statistical approach. Values are expressed as mean ± SD, number of cases and percentage. MTZ: Mestizos; TC: Total cholesterol; TG: Triglycerides; LDL-c: Low-density lipoprotein cholesterol; VLDL-c: Very low-density lipoprotein cholesterol; HDL-c: High-density lipoprotein cholesterol; HChol: Hypercholesterolemia; HTG: Hypertriglyceridemia; HALP: Hypoalphalipoproteinemia.

Citation: Torres-Valadez R, Roman S, Ojeda-Granados C, Gonzalez-Aldaco K, Panduro A. Differential distribution of gene polymorphisms associated with hypercholesterolemia, hypertriglyceridemia, and hypoalphalipoproteinemia among Native American and Mestizo Mexicans. World J Hepatol 2022; 14(7): 1408-1420
URL: https://www.wjgnet.com/1948-5182/full/v14/i7/1408.htm
DOI: https://dx.doi.org/10.4254/wjh.v14.i7.1408