Cardiac risk factors limiting survival to liver transplantation in patients with nonalcoholic fatty liver disease

Table 2 Univariate analysis on time to development of death/clinical deterioration prior to liver transplant

Variable	n	Events	Cox univariate hazard ratio (95%CI)	P value
Age	265	68 (26%)	1.018 (0.985, 1.053)	0.28
Sex
Female	137	38 (28%)	-
Male	128	30 (23%)	0.84 (0.52, 1.37)	0.49
Model for End-Stage Liver Disease	265	68 (26%)	1.18 (1.14, 1.23)	< 0.001
Body mass index	265	68 (26%)	0.975 (0.941, 1.011)	0.17
Renal replacement therapy
No	233	60 (26%)	-
Yes	32	8 (25%)	3.20 (1.49, 6.88)	0.003
Hypertension
No	113	29 (26%)	-
Yes	152	39 (26%)	1.15 (0.71, 1.88)	0.57
Obstructive sleep apnea
No	203	46 (23%)	-
Yes	62	22 (35%)	1.10 (0.66, 1.85)	0.72
Atrial fibrillation/Atrial flutter
No	256	64 (25%)	-
Yes	8	3 (38%)	2.97 (0.92, 9.61)	0.069
Heart failure				.
No	244	60 (25%)	-
Yes	18	8 (44%)	1.81 (0.86, 3.82)	0.12
Left ventricular ejection fraction	263	67 (25%)	0.99 (0.96, 1.03)	0.69
Estimated right ventricular systolic pressure	190	48 (25%)	1.026 (0.997, 1.055)	0.075
Aortic stenosis
No	257	67 (26%)	-
Yes	8	1 (13%)	0.95 (0.13, 6.86)	0.96
Aortic insufficiency
No	263	67 (25%)	-
Yes	2	1 (50%)	1.38 (0.19, 10.04)	0.75
Mitral regurgitation
No	261	67 (26%)	-
Yes	4	1 (25%)	2.92 (0.40, 21.48)	0.29
Tricuspid regurgitation
No	257	64 (25%)	-
Yes	8	4 (50%)	3.50 (1.26, 9.72)	0.016
CAD
No significant CAD	196	44 (22%)	-
Mild or Moderate CAD	45	15 (33%)	2.06 (1.14, 3.74)	0.017
Severe CAD	24	9 (38%)	2.43 (1.17, 5.05)	0.017
History of myocardial infarction
No	253	63 (25%)	-
Yes	12	5 (42%)	2.29 (0.92, 5.74)	0.076
History of coronary artery stenting
No	252	63 (25%)	-
Yes	13	5 (38%)	1.86 (0.74, 4.66)	0.19
History of coronary artery bypass grafting
No	254	64 (25%)	-
Yes	11	4 (36%)	2.03 (0.73, 5.65)	0.17
Hemoglobin A1c
< 5.6	59	12 (20%)	-	-
5.6-6.5	62	19 (31%)	1.11 (0.53, 2.32)	0.79
> 6.5	50	15 (30%)	0.80 (0.37, 1.76)	0.58
High-density lipoprotein
≥ 50	75	22 (29%)	-
< 50	176	41 (23%)	1.18 (0.69, 2.01)	0.54
Triglycerides
≤ 150	240	63 (26%)	-
> 150	15	2 (13%)	0.49 (0.12, 2.00)	0.32

CAD: Coronary artery disease.