Review
Copyright ©The Author(s) 2022.
World J Hepatol. Jun 27, 2022; 14(6): 1053-1073
Published online Jun 27, 2022. doi: 10.4254/wjh.v14.i6.1053
Table 1 Current diagnostic and tools to assess liver disease stages and severity in hepatitis C virus infected patients
Diagnostic tool
Early fibrosis stages (METAVIR less than F2)
Fibrosis 2
Fibrosis 3
Compensated cirrhosis
Decompensated cirrhosis
Ref.
HCV antibodyPositivePositivePositivePositivePositiveAASLD and IDSA[30]
Quantitative HCV RNA (viral load)PositivePositivePositivePositivePositive
Platelet count < 150000/mm3)NormalNormalNormal< 150000/mm3< 150000/mm3
Total and direct bilirubin, ALT & ASTNormal/elevatedNormal/elevatedNormal/elevatedElevatedElevated
Child- Pugh ------------------------Class A (scores 5-6)Class B (scores 7-9); Class C (scores 10-15)
FIB-4 Score< 1.45≥ 1.45 but < 2.67≥ 2.67 but < 3.25≥ 3.25> 3.25Filozof et al[31]
Fibroscan by transient elastography5.3 kPa7.4 kPa9.1 kPa13.2 kPa13.2 kPaPlaton et al[32]
Fibro test< 0.480.48 - 0.58> 0.58 but < 0.74> 0.74> 0.74Laboratory Corporation of America[33]
Enhanced liver fibrosis test< 7.77.79.811.311.3Lichtinghagen et al[34]
Aspartate aminotransferase to platelet ratio index < 0.770.770.77≥ 0.83≥ 0.83Lin et al[35]
Liver nodularity and/or splenomegalyNegativeNegativeNegativePositivePositiveAASLD and IDSA[30]
Prior liver biopsyF0: No fibrosis; F1: Portal fibrosis without septaF2: Portal Fibrosis with few septaF3: Numerous septa without cirrhosisF4: CirrhosisF4: Cirrhosis