Prognostic value of von-Willebrand factor in patients with liver cirrhosis and its relation to other prognostic indicators

Table 2 The relation between von-Willebrand factor and stage of disease, systemic inflammatory response syndrome, and other inflammatory and prognostic indicators¹

Parameter	vWF							P value
	n	mean ± SD	Min	Max	Percentiles
					25th	50th	75th
CTP score
Class A	18	258.0 ± 104.2	150	586	190.0	228.0	276.0	Kruskal-Wallis H test: Chi-square (2) = 10.8177; P = 0.0045a
Class B	25	336.5 ± 122.5	150	650	262.0	341.0	400.0
Class C	28	411.5 ± 182.2	198	850	246.0	402.8	560.0
Class А/B = Mann-Whitney U test: Z = -2.191; P = 0.028a
Class А/C = Mann-Whitney U test: Z = -3.028; P = 0.002a
Class B/C = Mann-Whitney U test: Z = -1.639; P = 0.101
MELD score
Group 1	9	271.5 ± 106.3	150	513	225.0	257.0	276.0	Kruskal-Wallis H test: Chi-square (2) = 10.3357; P = 0.0057a
Group 2	33	301.0 ± 115.9	161	650	200.0	296.0	350.0
Group 3	29	420.8 ± 179.7	150	850	258.0	409.0	548.0
Group 1/2 = Mann-Whitney U test: Z = -0.690; P = 0.507
Group 1/3 = Mann-Whitney U test: Z = -0.031; P = 0.029a
Group 2/3 = Mann-Whitney U test: Z = -2.942; P = 0.003a
SIRS score
SIRS (+)	43	339.2 ± 142.0	150	680	200.0	336.5	409.0	Mann-Whitney U test: Z = -0.3529; P = 0.7241
SIRS (-)	28	356.9 ± 177.5	150	850	216.0	309.2	410.8
Ferritin (ng/mL)
< 200	39	310.0 ± 140.7	150.0	650.0	198.0	262.0	405.0	Kruskal-Wallis H test: Chi-square (2) = 7.1653; P = 0.0278a
200-400	5	343.3 ± 91.2	253.0	458.9	258.0	336.5	410.1
> 400	18	423.9 ± 171.0	199.7	850.0	300.0	400.5	548.0
< 200/200-400 = Mann-Whitney U test: Z = -0.292; P = 0.311
< 200/> 400 = Mann-Whitney U test: Z = -2.584; P = 0.010a
200-400/> 400 = Mann-Whitney U test: Z = -0.820; P = 0.446
Vitamin D (ng/mL)
≤ 20	22	279.8 ± 108.9	150.0	513.0	199.7	241.0	344.0	Mann-Whitney U test: Z = -1.6916; P = 0.0907
> 20	23	372.0 ± 179.8	161.0	850.0	214.0	385.0	458.9
PLT (109/ L)
≤ 100	40	350.8 ± 171.4	161	850	207.2	312.7	412.1	Mann-Whitney U test: Z = -0.02898; P = 0.9769
> 100	31	340.2 ± 136.0	150	598	239.0	337.0	405.0
D-dimer (µg/mL)
≤ 500	6	205.2 ± 38.5	150	262	187.2	203.5	225.0	Mann-Whitney U test: Z = 2.6407; P = 0.0083a
> 500	63	355.9 ± 156.2	150	850	216.0	337.0	411.5

¹The values are expressed as mean ± standard deviation (SD).

^aP< 0.05.

von-Willebrand factor (vWF) was significantly higher in higher Child-Turcotte-Pugh (CTP) class, model for end-stage liver disease (MELD) group, serum ferritin (SF) group and in patients with elevated D-dimer level. SIRS: Systemic inflammatory response syndrome; PLT: Platelets.