Hepatitis E in immunocompromised individuals

Table 1 Hepatitis E epidemiology according to genotypes

	HEV1, HEV2	HEV3, HEV4
Geography	Developing countries (Asia, Africa, and South America)	Developed countries (Europe, United states, Japan, and Hong Kong)
Disease pattern	Endemic	Sporadic
Seasonal pattern	Yes	No
Reservoir	Only human	Animals (Pigs, wild boars, deer)
Transmission	Fecal-oral	Food-born, blood products, transplantation
Age	More common among young adult	More common among older adults
Risk factor	Chronic liver disease, pregnancy	Chronic liver disease, immunocompromised
Safety measure	Clean water, sanitation, and hygiene	Avoid contact with high-risk animals, cook meat adequately
Chronic infection	Not reported	In immunocompromised patients.

HEV1: Hepatitis E virus genotype 1; HEV2: Hepatitis E virus genotype 2; HEV3: Hepatitis E virus genotype 3; HEV4: Hepatitis E virus genotype 4.