β-arrestin-2 predicts the clinical response to β-blockers in cirrhotic portal hypertension patients: A prospective study

doi:10.4254/wjh.v14.i2.429

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Prospective Study

World J Hepatol. Feb 27, 2022; 14(2): 429-441
Published online Feb 27, 2022. doi: 10.4254/wjh.v14.i2.429

Table 2 Univariate and multivariate analysis for predictors of diminished β-Arrestin-2 expression after nonselective β-blockers

Parameters	Univariate analysis		Multivariate analysis
	P value	OR	P value	OR	95%CI
ALT	0.51	-	-	-	-
AST	0.20	-	-	-	-
Platelets	0.26	-	-	-	-
APRI	0.06	-	-	-	-
Albumen	0.25	-	-	-	-
Bilirubin	0.69	-	-	-	-
Child-Turcotte-Pugh class	0.73	-	-	-	-
Baseline EV grade	0.003	1.35	-	-	-
Baseline β-Arr-2 expression	< 0.001	2.41	-	-	-
NSBB dose	0.049	6.5	0.02	1.01	0.91-1.05
ΔPVCI	< 0.001	10.34	0.005	1.58	0.001- 0.002

ALT: Alanine aminotransferase; APRI: Aspartate aminotransferase/platelet ratio index; AST: Aspartate aminotransferase; β-Arr-2: β-Arrestin-2; ΔPVCI: Delta (change in) portal vein congestion index; EV: Esophageal varices; NSBB: Nonselective beta-blockers.

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Citation: Lashen SA, Shamseya MM, Madkour MA, Abdel Salam RM, Mostafa SS. β-arrestin-2 predicts the clinical response to β-blockers in cirrhotic portal hypertension patients: A prospective study. World J Hepatol 2022; 14(2): 429-441
URL: https://www.wjgnet.com/1948-5182/full/v14/i2/429.htm
DOI: https://dx.doi.org/10.4254/wjh.v14.i2.429

Lashen SA, Shamseya MM, Madkour MA, Abdel Salam RM, Mostafa SS. β-arrestin-2 predicts the clinical response to β-blockers in cirrhotic portal hypertension patients: A prospective study. World J Hepatol 2022; 14(2): 429-441 [PMID: 35317175 DOI: 10.4254/wjh.v14.i2.429]

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