Cytomegalovirus infection in liver-transplanted children

doi:10.4254/wjh.v14.i2.338

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World Journal of Hepatology

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1948-5182

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World J Hepatol. Feb 27, 2022; 14(2): 338-353
Published online Feb 27, 2022. doi: 10.4254/wjh.v14.i2.338

Table 1 Risk of cytomegalovirus disease after liver transplantation

Risk factors
CMV serostatus of recipient and donor	D⁺/R⁻
CMV serostatus of recipient and donor	D⁺/R⁺ and D⁻/R⁺
Viral burden (initial CMV viral load)	High CMV viral load
Viral burden (initial CMV viral load)	Rate of viral load increasing
Immunosuppressive agents	Antibody to CD3-receptor: OKT3 or muromonab
	Basiliximab
	Corticosteroids
	Mycophenolate mofetil
	Calcineurin inhibitors: Tacrolimus, sirolimus, and cyclosporine
Recipient immunity	TLR2 gene mutation, mutation of mannose-binding lectin
Recipient immunity	Upregulation of programmed death-1 receptors
Recipient underlying liver disease	Hepatoblastoma with pre-transplant chemotherapy
Other risk factors	Virus-to-virus interaction (HHV6, HCV, fungal infection), transfusion of non-leucocyte-depleted blood products, volume of blood loss, liver transplantation because of fulminant liver failure, older age, non-white race, female sex, CVVH after liver transplant, septic shock, renal insufficiency

CMV: Cytomegalovirus; CVVH: Continuous venovenous haemofiltration; D: Donor; HCV: Hepatitis C virus; HHV-6: Human herpes virus-6; R: Recipient; TLR2: Toll-like receptor 2.

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Citation: Onpoaree N, Sanpavat A, Sintusek P. Cytomegalovirus infection in liver-transplanted children. World J Hepatol 2022; 14(2): 338-353
URL: https://www.wjgnet.com/1948-5182/full/v14/i2/338.htm
DOI: https://dx.doi.org/10.4254/wjh.v14.i2.338

Onpoaree N, Sanpavat A, Sintusek P. Cytomegalovirus infection in liver-transplanted children. World J Hepatol 2022; 14(2): 338-353 [PMID: 35317177 DOI: 10.4254/wjh.v14.i2.338]

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