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World J Hepatol. Nov 27, 2022; 14(11): 1931-1939
Published online Nov 27, 2022. doi: 10.4254/wjh.v14.i11.1931
Figure 1
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Figure 1 Mechanism of iron overload in HFE-related hemochromatosis. The C282Y/C282Y mutations (homozygosity for C282Y) lead to decreased synthesis of the iron hormone hepcidin, which in turn causes an increased activity of the iron export protein ferroportin both at the digestive and splenic levels. The result is increased plasma iron leading to organ iron overload.