Observational Study
Copyright ©The Author(s) 2022.
World J Hepatol. Nov 27, 2022; 14(11): 1964-1976
Published online Nov 27, 2022. doi: 10.4254/wjh.v14.i11.1964
Table 1 Characteristics of included patients
Parameter
Stable cirrhosis (n = 20)
Acute decompensation (n = 200)
P value
Age (yr), mean ± SD51.35 ± 12.6857.29 ± 11.560.056
Male gender, n (%)15 (75.0)143 (71.5)0.740
Etiology of cirrhosis1, n (%)
Alcohol12 (60.0)106 (53.0)0.549
Hepatitis C6 (30.0)58 (29.0)0.925
Hepatitis B 3 (15.0)10 (5.0)0.102
Cryptogenicautoimmune2 (10.0)8 (4.0)0.229
Autoimmune0 (0.0)11 (5.5)0.605
NASH0 (0.0)25 (12.6)0.139
Other22 (10.0)11 (5.5)0.335
Active alcoholism, n (%)0 (0.0)34 (17.0)0.049
Prior decompensation, n (%)15 (75.0)173 (86.5)0.182
Laboratory data
Leukocyte count (×109), median4.966.540.008
Sodium (mEq/L), mean ± SD138.05 ± 1.50136.24 ± 5.21< 0.001
Creatinine (mg/dL), median0.81.11< 0.001
INR, median1.151.46< 0.001
Albumin (g/dL), mean ± SD3.54 ± 0.342.63 ± 0.68< 0.001
CRP (mg/L), median3.018.2< 0.001
Total bilirubin (mg/dL), median1.102.20< 0.001
Calprotectin (ng/dL), median396.5477.20.127
Child-Pugh score, mean ± SD6.40 ± 1.609.24 ± 1.92< 0.001
Child-Pugh A, n (%)13 (65.0)12 (6.0)< 0.001
Child-Pugh B, n (%)6 (30.0)97 (48.5)0.114
Child-Pugh C, n (%)1 (5.0)91 (45.5)< 0.001
MELD score, mean ± SD9.4 ± 1.817.6 ± 7.0< 0.001
Complication at evaluation, n (%)
Ascites2 (10.0)125 (62.5)< 0.001
Hepatic encephalopathy3 (15.0)99 (48.5)< 0.001
Gastrointestinal bleeding-66 (33.0)
Bacterial infection-70 (35.0)
Alcoholic hepatitis-11 (5.5)
CLIF-SOFA, median-7.00
ACLF, n (%)-56 (28.0)
ACLF grade, n (%)
Grade 1-37 (18.5)
Grade 2-11 (5.5)
Grade 3-8 (4.0)